Hesperadin hydrochloride | Tocris Bioscience 3988 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Hesperadin hydrochloride

catalog :

3988

quantity :

10 mg (also 50 mg)

price :

300 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Hauf S, Cole R, LaTerra S, Zimmer C, Schnapp G, Walter R, et al. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol. 2003;161:281-94 pubmed

product information

brand :

Tocris

master code :

3988

SKU :

3988/10

product name :

Hesperadin hydrochloride

description :

Potent Aurora kinase B inhibitor

target :

Aurora Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

553.12

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ATP-competitive inhibitor of Aurora B kinase (IC50 = 250 nM). Prevents chromosome alignment and segregation; also induces polyploidy and prevents histone H3-Ser10 phosphorylation. Overrides the spindle assembly checkpoint and induces mitotic exit in monastrol - and taxol -treated HeLa cells. Inhibits replication of influenza A and B viral strains (IC50 values range from 0.22 M to 1.8 M, dependant on strain), by inhibiting viral RNA transcription and translation

catalog number base :

3988

product keywords :

aurora B kinase inhibitors inhibits ATP-competitive 422513-13-1 antiviral influenza virus Aurora Kinases Influenza Viruses 3988,

extended description :

Potent Aurora kinase B inhibitor

chemical name text :

N-[2,3-Dihydro-2-oxo-3-[(3Z)-phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indol-5-yl]-ethanesulfonamide hydrochloride

formula :

C 29 H 32 N 4 O 3 S.HCl

formula text :

C29H32N4O3S.HCl

2020 USD :

288

2021 USD :

300 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage