Hesperadin hydrochloride | Tocris Bioscience 3988/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Hesperadin hydrochloride

catalog :

3988/10

quantity :

10 mg (also 50 mg)

price :

347 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Hauf S, Cole R, LaTerra S, Zimmer C, Schnapp G, Walter R, et al. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol. 2003;161:281-94 pubmed

product information

brand :

Tocris

master code :

3988

SKU :

3988/10

rank :

0.071

product name :

Hesperadin hydrochloride

description :

Potent Aurora kinase B inhibitor

target :

Aurora Kinase Inhibitors

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Hesperadin hydrochloride is an ATP-competitive inhibitor of Aurora B kinase (IC50 = 250 nM). Prevents chromosome alignment and segregation; also induces polyploidy and prevents histone H3-Ser10 phosphorylation. Overrides the spindle assembly checkpoint and induces mitotic exit in monastrol - and taxol -treated HeLa cells. Inhibits replication of influenza A and B viral strains (IC50 values range from 0.22 M to 1.8 M, dependant on strain), by inhibiting viral RNA transcription and translation

extended description :

Potent Aurora kinase B inhibitor

chemical name text :

N-[2,3-Dihydro-2-oxo-3-[(3Z)-phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indol-5-yl]-ethanesulfonamide hydrochloride

formula :

C 29 H 32 N 4 O 3 S.HCl

formula text :

C29H32N4O3S.HCl

USD :

347 USD

product details :

Potent Aurora kinase B inhibitor

storage :

Store the unopened product at room temperature. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage