Nutlin-3 | Tocris Bioscience 3984 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Nutlin-3

catalog :

3984

quantity :

10 mg (also 50 mg)

price :

288 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Norlin S, Parekh V, Edlund H. The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival. Development. 2018;145: pubmed publisher
Yang K, Wang M, Zhao Y, Sun X, Yang Y, Li X, et al. A redox mechanism underlying nucleolar stress sensing by nucleophosmin. Nat Commun. 2016;7:13599 pubmed publisher
Bussey K, Bapat A, Linnehan C, Wandoloski M, Dastrup E, Rogers E, et al. Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma. Clin Transl Med. 2016;5:1 pubmed publisher

product information

brand :

Tocris

master code :

3984

SKU :

3984/10

product name :

Nutlin-3

description :

MDM2 antagonist; inhibits MDM2-p53 interaction

target :

p53 Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

581.49

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 M) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.

catalog number base :

3984

product keywords :

Nutlin3 p53 activator MDM2 antagonist antagonists p53-MDM2 p53 Ubiquitin E3 Ligases 3984,

extended description :

MDM2 antagonist; inhibits MDM2-p53 interaction

chemical name text :

( )-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one

formula :

C 30 H 30 Cl 2 N 4 O 4

formula text :

C30H30Cl2N4O4

cas num :

548472-68-0

2020 USD :

276

2021 USD :

288 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage