Nutlin-3 | Tocris Bioscience 3984/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Nutlin-3

catalog :

3984/10

quantity :

10 mg

price :

334 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Norlin S, Parekh V, Edlund H. The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival. Development. 2018;145: pubmed publisher
Yang K, Wang M, Zhao Y, Sun X, Yang Y, Li X, et al. A redox mechanism underlying nucleolar stress sensing by nucleophosmin. Nat Commun. 2016;7:13599 pubmed publisher
Bussey K, Bapat A, Linnehan C, Wandoloski M, Dastrup E, Rogers E, et al. Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma. Clin Transl Med. 2016;5:1 pubmed publisher

product information

brand :

Tocris

master code :

3984

SKU :

3984/10

rank :

0.061

product name :

Nutlin-3

description :

MDM2 antagonist; inhibits MDM2-p53 interaction

target :

p53 Inhibitors

category :

Small Molecules

sizes available :

10 mg

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Nutlin-3 is a MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 M) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.

extended description :

MDM2 antagonist; inhibits MDM2-p53 interaction

chemical name text :

( )-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one

formula :

C 30 H 30 Cl 2 N 4 O 4

formula text :

C30H30Cl2N4O4

cas num :

548472-68-0

USD :

334 USD

product details :

MDM2 antagonist; inhibits MDM2-p53 interaction

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage