product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
PSB 0739
catalog :
3983/10
quantity :
10 mg (also 50 mg)
price :
241 USD
more info or order :
citations: 9
Reference
Cserép C, Pósfai B, Lénárt N, Fekete R, László Z, Lele Z, et al. Microglia monitor and protect neuronal function through specialized somatic purinergic junctions. Science. 2020;367:528-537 pubmed publisher
Uderhardt S, Martins A, Tsang J, Lämmermann T, Germain R. Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell. 2019;177:541-555.e17 pubmed publisher
Madry C, Kyrargyri V, Arancibia Carcamo I, Jolivet R, Kohsaka S, Bryan R, et al. Microglial Ramification, Surveillance, and Interleukin-1? Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1. Neuron. 2018;97:299-312.e6 pubmed publisher
Smith T, Li J, Dores M, Trejo J. Protease-activated receptor-4 and purinergic receptor P2Y12 dimerize, co-internalize, and activate Akt signaling via endosomal recruitment of β-arrestin. J Biol Chem. 2017;292:13867-13878 pubmed publisher
Abud E, Ramirez R, Martinez E, Healy L, Nguyen C, Newman S, et al. iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases. Neuron. 2017;94:278-293.e9 pubmed publisher
Aungraheeta R, Conibear A, Butler M, Kelly E, Nylander S, Mumford A, et al. Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor. Blood. 2016;128:2717-2728 pubmed
Takayama F, Hayashi Y, Wu Z, Liu Y, Nakanishi H. Diurnal dynamic behavior of microglia in response to infected bacteria through the UDP-P2Y6 receptor system. Sci Rep. 2016;6:30006 pubmed publisher
Nishimura Y, McLaughlin N, Pan J, Goldstein S, Hafenstein S, Shimizu H, et al. The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate. PLoS Pathog. 2015;11:e1005184 pubmed publisher
Wang W, Luo J, Xiang F, Liu X, Jiang M, Liao L, et al. Nucleolin down-regulation is involved in ADP-induced cell cycle arrest in S phase and cell apoptosis in vascular endothelial cells. PLoS ONE. 2014;9:e110101 pubmed publisher
product information
brand :
Tocris
master code :
3983
SKU :
3983/10
rank :
0.061
product name :
PSB 0739
description :
Highly potent P2Y12 antagonist
target :
P2Y Receptor Antagonists
category :
Small Molecules
sizes available :
10 mg (also 50 mg)
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
PSB 0739 is a highly potent P2Y12 receptor antagonist (Ki = 24.9 nM). Unlike clopidogrel (Cat. No. 2490), does not require bioactivation.
extended description :
Highly potent P2Y12 antagonist
chemical name text :
1-Amino-9,10-dihydro-9,10-dioxo-4-[[4-(phenylamino)-3-sulfophenyl]amino]-2-anthracenesulfonic acid sodium salt
formula :
C 26 H 17 N 3 Na 2 O 8 S 2
formula text :
C26H17N3Na2O8S2
cas num :
1052087-90-7
USD :
241 USD
product details :
Highly potent P2Y12 antagonist
storage :
Store the unopened product at room temperature. Do not use past expiration date.
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK