Mdivi 1 | Tocris Bioscience 3982 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Mdivi 1

catalog :

3982

quantity :

10 mg (also 50 mg)

price :

102 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Tsuyoshi H, Wong V, Han Y, Orisaka M, Yoshida Y, Tsang B. Saikosaponin-d, a calcium mobilizing agent, sensitizes chemoresistant ovarian cancer cells to cisplatin-induced apoptosis by facilitating mitochondrial fission and G2/M arrest. Oncotarget. 2017;8:99825-99840 pubmed publisher
Xu X, Luo C, Zhang Z, Hu J, Gao X, Zuo Y, et al. Mdivi‑1 attenuates sodium azide‑induced apoptosis in H9c2 cardiac muscle cells. Mol Med Rep. 2017;16:5972-5978 pubmed publisher
Iqbal S, Hood D. Oxidative stress-induced mitochondrial fragmentation and movement in skeletal muscle myoblasts. Am J Physiol Cell Physiol. 2014;306:C1176-83 pubmed publisher
Gharanei M, Hussain A, Janneh O, Maddock H. Attenuation of doxorubicin-induced cardiotoxicity by mdivi-1: a mitochondrial division/mitophagy inhibitor. PLoS ONE. 2013;8:e77713 pubmed publisher

product information

brand :

Tocris

master code :

3982

SKU :

3982/10

product name :

Mdivi 1

description :

Selective dynamin inhibitor; attenuates mitochondrial division and apoptosis

target :

Dynamin Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

353.22

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective inhibitor of Dnm1 GTPase (IC50 = 1 - 10 M); attenuates Dnm1- and Drp1-mediated mitochondrial division. Inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis. Inhibits autophagy.

catalog number base :

3982

product keywords :

selective inhibitors inhibits inhibitor dynamin Dnm1 dynamin-related GTPases DRP attenuates mitochondrial division Mdivi1 DRP1 Other Apoptosis Mitosis Autophagy Dynamin 3982,

extended description :

Selective dynamin inhibitor; attenuates mitochondrial division and apoptosis

chemical name text :

3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone

formula :

C 15 H 10 C l2 N 2 O 2 S

formula text :

C15H10Cl2N2O2S

cas num :

338967-87-6

2020 USD :

2021 USD :

102 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage