Mdivi 1 | Tocris Bioscience 3982/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Mdivi 1

catalog :

3982/10

quantity :

10 mg (also 50 mg)

price :

119 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Tsuyoshi H, Wong V, Han Y, Orisaka M, Yoshida Y, Tsang B. Saikosaponin-d, a calcium mobilizing agent, sensitizes chemoresistant ovarian cancer cells to cisplatin-induced apoptosis by facilitating mitochondrial fission and G2/M arrest. Oncotarget. 2017;8:99825-99840 pubmed publisher
Xu X, Luo C, Zhang Z, Hu J, Gao X, Zuo Y, et al. Mdivi‑1 attenuates sodium azide‑induced apoptosis in H9c2 cardiac muscle cells. Mol Med Rep. 2017;16:5972-5978 pubmed publisher
Iqbal S, Hood D. Oxidative stress-induced mitochondrial fragmentation and movement in skeletal muscle myoblasts. Am J Physiol Cell Physiol. 2014;306:C1176-83 pubmed publisher
Gharanei M, Hussain A, Janneh O, Maddock H. Attenuation of doxorubicin-induced cardiotoxicity by mdivi-1: a mitochondrial division/mitophagy inhibitor. PLoS ONE. 2013;8:e77713 pubmed publisher

product information

brand :

Tocris

master code :

3982

SKU :

3982/10

rank :

0.061

product name :

Mdivi 1

description :

Selective dynamin inhibitor; attenuates mitochondrial division and apoptosis

target :

Dynamin Inhibitors

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Mdivi 1 is a selective inhibitor of dynamin GTPase (IC50 = 1 - 10 M); attenuates Dnm1- and Drp1-mediated mitochondrial division. Mdivi 1 inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis. In cancer cell lines, Mdivi 1 reduces cell proliferation; in an animal model of ischemic retina Mdivi 1 treatment blocks apoptosis. In a cell model, Mdivi 1 protects against mutant huntington-induced damage and mitochondrial dysfunction. Mdivi 1 also inhibits autophagy and protects neurons from excitotoxicity.

extended description :

Selective dynamin inhibitor; attenuates mitochondrial division and apoptosis

chemical name text :

3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone

formula :

C 15 H 10 C l2 N 2 O 2 S

formula text :

C15H10Cl2N2O2S

cas num :

338967-87-6

USD :

119 USD

product details :

Selective dynamin inhibitor; attenuates mitochondrial division and apoptosis

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage