AZD 5438 | Tocris Bioscience 3968 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AZD 5438

catalog :

3968

quantity :

10 mg (also 50 mg)

price :

258 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Goonesekere N, Wang X, Ludwig L, Guda C. A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers. PLoS ONE. 2014;9:e93046 pubmed publisher
Natrajan R, Mackay A, Wilkerson P, Lambros M, Wetterskog D, Arnedos M, et al. Functional characterization of the 19q12 amplicon in grade III breast cancers. Breast Cancer Res. 2012;14:R53 pubmed

product information

brand :

Tocris

master code :

3968

SKU :

3968/10

product name :

AZD 5438

description :

Cdk inhibitor; potently inhibits cdk1, 2, 5 and 9

target :

Cyclin-dependent Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

371.46

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent inhibitor of cyclin dependent kinases (cdks; reported IC50 values are 6 - 45, 14, 16 and 20 nM for cdk2, cdk5, cdk1 and cdk9 respectively). Also inhibits cdk4 and cdk7 in the sub micromolar range. Exhibits antiproliferative activity in human tumor cell lines. Blocks cell cycling at G2-M, S and G1 phases; reduces the proportion of actively cycling cells in vivo .

catalog number base :

3968

product keywords :

AZD5438 Cdk inhibitor cyclin-dependent kinase inhibitors inhibits cdk1 cdk2 cdk9 Cyclin-dependent Kinase Cell Cycle Inhibitors 3968,

extended description :

Cdk inhibitor; potently inhibits cdk1, 2, 5 and 9

chemical name text :

4-[2-Methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine

formula :

C 18 H 21 N 5 O 2 S

formula text :

C18H21N5O2S

cas num :

602306-29-6

2020 USD :

250

2021 USD :

258 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage