AZM 475271 | Tocris Bioscience 3963 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AZM 475271

catalog :

3963

quantity :

10 mg (also 50 mg)

price :

271 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Gautam J, Banskota S, Regmi S, Ahn S, Jeon Y, Jeong H, et al. Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling. Mol Cancer. 2016;15:75 pubmed
Wang Y, Gratzke C, Tamalunas A, Rutz B, Ciotkowska A, Strittmatter F, et al. Smooth muscle contraction and growth of stromal cells in the human prostate are both inhibited by the Src family kinase inhibitors, AZM475271 and PP2. Br J Pharmacol. 2016;173:3342-3358 pubmed publisher
Thakur R, Trivedi R, Rastogi N, Singh M, Mishra D. Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer. Sci Rep. 2015;5:10194 pubmed publisher
Leoni G, Alam A, Neumann P, Lambeth J, Cheng G, McCoy J, et al. Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest. 2013;123:443-54 pubmed publisher

product information

brand :

Tocris

master code :

3963

SKU :

3963/10

product name :

AZM 475271

description :

Src tyrosine kinase inhibitor

target :

Src Family Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

442.94

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Src tyrosine kinase inhibitor. Reduces tumor size, vascularity and metastasis, and increases apoptosis in human pancreatic cells grown in nude mice. Also exhibits antiangiogenic activity in vitro and in vivo . Sensitizes tumor cells to the cytotoxic effects of gemcitabine (Cat. No. 3259).

catalog number base :

3963

product keywords :

AZM475271 inhibits Src family tyrosine kinase inhibitors astrazeneca Src Kinases 3963,

extended description :

Src tyrosine kinase inhibitor

chemical name text :

N-(2-Chloro-5-methoxyphenyl)-6-methoxy

formula :

C 23 H 27 ClN 4 O 3

formula text :

C23H27ClN4O3

cas num :

476159-98-5

2020 USD :

263

2021 USD :

271 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage