kb NB 142-70 | Tocris Bioscience 3962 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

kb NB 142-70

catalog :

3962

quantity :

10 mg (also 50 mg)

price :

263 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Zhang Z, Meszaros G, He W, Xu Y, de Fatima Magliarelli H, Mailly L, et al. Protein kinase D at the Golgi controls NLRP3 inflammasome activation. J Exp Med. 2017;214:2671-2693 pubmed publisher
Xiong J, Zhou M, Wang Y, Chen L, Xu W, Wang Y, et al. Protein Kinase D2 Protects against Acute Colitis Induced by Dextran Sulfate Sodium in Mice. Sci Rep. 2016;6:34079 pubmed publisher
Weber P, Hornjik M, Olayioye M, Hausser A, Radde N. A computational model of PKD and CERT interactions at the trans-Golgi network of mammalian cells. BMC Syst Biol. 2015;9:9 pubmed publisher

product information

brand :

Tocris

master code :

3962

SKU :

3962/10

product name :

kb NB 142-70

description :

Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327)

target :

Protein Kinase D Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

251.32

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective protein kinase D (PKD) inhibitor (IC50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively). More potent analog of CID 755673 (Cat. No. 3327) with 7-fold greater inhibition. Inhibits prostrate cancer cell migration and invasion and reduces wound healing in vitro ; displays prominent cytotoxic and anti-proliferative effects.

catalog number base :

3962

product keywords :

PKD protein kinase D inhibitor analog selective inhibitors inhibits analogs kbNB142-70 Protein Kinase D 3962,

extended description :

Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327)

chemical name text :

9-Hydroxy-3,4-dihydro-2H-[1]-benzothiolo[2,3-f][1,4]thiazepin-5-one

formula :

C 11 H 9 NO 2 S 2

formula text :

C11H9NO2S2

cas num :

1233533-04-4

2020 USD :

255

2021 USD :

263 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage