kb NB 142-70 | Tocris Bioscience 3962/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

kb NB 142-70

catalog :

3962/10

quantity :

10 mg (also 50 mg)

price :

295 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Oueslati Morales C, Ignácz A, Bencsik N, Szíber Z, Rátkai A, Lieb W, et al. Protein kinase D promotes activity-dependent AMPA receptor endocytosis in hippocampal neurons. Traffic. 2021;22:454-470 pubmed publisher
Zhang Z, Meszaros G, He W, Xu Y, de Fatima Magliarelli H, Mailly L, et al. Protein kinase D at the Golgi controls NLRP3 inflammasome activation. J Exp Med. 2017;214:2671-2693 pubmed publisher
Chang J, Ni Y, Han L, Sinnett Smith J, Jacamo R, Rey O, et al. Protein kinase D1 (PKD1) phosphorylation on Ser203 by type I p21-activated kinase (PAK) regulates PKD1 localization. J Biol Chem. 2017;292:9523-9539 pubmed publisher
Hao F, Xu Q, Zhao Y, Stevens J, Young S, Sinnett Smith J, et al. Insulin Receptor and GPCR Crosstalk Stimulates YAP via PI3K and PKD in Pancreatic Cancer Cells. Mol Cancer Res. 2017;15:929-941 pubmed publisher
Xiong J, Zhou M, Wang Y, Chen L, Xu W, Wang Y, et al. Protein Kinase D2 Protects against Acute Colitis Induced by Dextran Sulfate Sodium in Mice. Sci Rep. 2016;6:34079 pubmed publisher
Weber P, Hornjik M, Olayioye M, Hausser A, Radde N. A computational model of PKD and CERT interactions at the trans-Golgi network of mammalian cells. BMC Syst Biol. 2015;9:9 pubmed publisher
Gan H, Wang G, Hao Q, Wang Q, Tang H. Protein kinase D promotes airway epithelial barrier dysfunction and permeability through down-regulation of claudin-1. J Biol Chem. 2013;288:37343-54 pubmed publisher

image

image 1 :

Cat.No. 3962 - kb NB 142-70 C11H9NO2S2 CAS No. 1233533-04-4

product information

brand :

Tocris

catalog number base :

3962

SKU :

3962/10

product name :

kb NB 142-70

units size :

10 mg (also 50 mg)

description :

Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327)

target :

Protein Kinase D Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

251.32

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

kb NB 142-70 is a selective protein kinase D (PKD) inhibitor (IC50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively). More potent analog of CID 755673 (Cat. No. 3327) with 7-fold greater inhibition. Inhibits prostrate cancer cell migration and invasion and reduces wound healing in vitro ; displays prominent cytotoxic and anti-proliferative effects.

top caption :

Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327)

extended description :

Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327)

chemical name text :

9-Hydroxy-3,4-dihydro-2H-[1]-benzothiolo[2,3-f][1,4]thiazepin-5-one

formula :

C11H9NO2S2

formula text :

C11H9NO2S2

cas num :

1233533-04-4

USD :

295 USD

product details :

Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327)

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage