kb NB 142-70 | Tocris Bioscience 3962/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

kb NB 142-70

catalog :

3962/10

quantity :

10 mg (also 50 mg)

price :

305 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Zhang Z, Meszaros G, He W, Xu Y, de Fatima Magliarelli H, Mailly L, et al. Protein kinase D at the Golgi controls NLRP3 inflammasome activation. J Exp Med. 2017;214:2671-2693 pubmed publisher
Xiong J, Zhou M, Wang Y, Chen L, Xu W, Wang Y, et al. Protein Kinase D2 Protects against Acute Colitis Induced by Dextran Sulfate Sodium in Mice. Sci Rep. 2016;6:34079 pubmed publisher
Weber P, Hornjik M, Olayioye M, Hausser A, Radde N. A computational model of PKD and CERT interactions at the trans-Golgi network of mammalian cells. BMC Syst Biol. 2015;9:9 pubmed publisher

image

image 1 :

Cat.No. 3962 - kb NB 142-70 C11H9NO2S2 CAS No. 1233533-04-4

product information

brand :

Tocris

master code :

3962

SKU :

3962/10

rank :

0.061

product name :

kb NB 142-70

description :

Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327)

target :

Protein Kinase D Inhibitors

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

kb NB 142-70 is a selective protein kinase D (PKD) inhibitor (IC50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively). More potent analog of CID 755673 (Cat. No. 3327) with 7-fold greater inhibition. Inhibits prostrate cancer cell migration and invasion and reduces wound healing in vitro ; displays prominent cytotoxic and anti-proliferative effects.

extended description :

Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327)

chemical name text :

9-Hydroxy-3,4-dihydro-2H-[1]-benzothiolo[2,3-f][1,4]thiazepin-5-one

formula :

C 11 H 9 NO 2 S 2

formula text :

C11H9NO2S2

cas num :

1233533-04-4

USD :

305 USD

product details :

Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327)

storage :

Store the unopened product at room temperature. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage