YIL 781 hydrochloride | Tocris Bioscience 3959 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

YIL 781 hydrochloride

catalog :

3959

quantity :

25 mg

price :

476 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Tóth K, Slosky L, Pack T, Urs N, Boone P, Mao L, et al. Ghrelin receptor antagonism of hyperlocomotion in cocaine-sensitized mice requires ?arrestin-2. Synapse. 2018;72: pubmed publisher
Evron T, Peterson S, Urs N, Bai Y, Rochelle L, Caron M, et al. G Protein and Î²-arrestin signaling bias at the ghrelin receptor. J Biol Chem. 2014;289:33442-55 pubmed publisher
Song L, Zhu Q, Liu T, Yu M, Xiao K, Kong Q, et al. Ghrelin modulates lateral amygdala neuronal firing and blocks acquisition for conditioned taste aversion. PLoS ONE. 2013;8:e65422 pubmed publisher

product information

brand :

Tocris

master code :

3959

SKU :

3959/25

product name :

YIL 781 hydrochloride

description :

Ghrelin receptor (GHS-R1a) antagonist

target :

Ghrelin Receptor Antagonists

category :

Small Molecules

unit size :

25 mg

purity :

98%

observed molecular weight :

445.96

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Ghrelin receptor antagonist (GHS-R1a) (Ki = 17 nM). Displays no significant affinity for the motilin receptor (Ki = 6 M). Blocks the effects of ghrelin on insulin secretion both in vivo and in vitro . Improves glucose homeostasis in vivo .

catalog number base :

3959

product keywords :

YIL781 YIL 781 hydrochloride HCl ghrelin receptors antagonists GHS-R1a GHSR Ghrelin Receptors 3959,

extended description :

Ghrelin receptor (GHS-R1a) antagonist

chemical name text :

6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone hydrochloride

formula :

C 24 H 28 FN 3 O 2 .HCl

formula text :

C24H28FN3O2.HCl

cas num :

1640226-17-0

2020 USD :

457

2021 USD :

476 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage