YIL 781 hydrochloride | Tocris Bioscience 3959/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

YIL 781 hydrochloride

catalog :

3959/5

quantity :

5 mg (also 25 mg)

price :

158 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Tóth K, Nagi K, Slosky L, Rochelle L, Ray C, Kaur S, et al. Encoding the β-Arrestin Trafficking Fate of Ghrelin Receptor GHSR1a: C-Tail-Independent Molecular Determinants in GPCRs. ACS Pharmacol Transl Sci. 2019;2:230-246 pubmed publisher
Tóth K, Slosky L, Pack T, Urs N, Boone P, Mao L, et al. Ghrelin receptor antagonism of hyperlocomotion in cocaine-sensitized mice requires ?arrestin-2. Synapse. 2018;72: pubmed publisher
Evron T, Peterson S, Urs N, Bai Y, Rochelle L, Caron M, et al. G Protein and Î²-arrestin signaling bias at the ghrelin receptor. J Biol Chem. 2014;289:33442-55 pubmed publisher
Song L, Zhu Q, Liu T, Yu M, Xiao K, Kong Q, et al. Ghrelin modulates lateral amygdala neuronal firing and blocks acquisition for conditioned taste aversion. PLoS ONE. 2013;8:e65422 pubmed publisher

image

image 1 :

Cat.No. 3959 - YIL 781 hydrochloride C24H28FN3O2.HCl CAS No. 1640226-17-0

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3959

SKU :

3959/5

product name :

YIL 781 hydrochloride

description :

Ghrelin receptor (GHS-R1a) antagonist

target :

Ghrelin Receptor Antagonists

unit size :

5 mg (also 25 mg)

category :

Small Molecules

purity :

98%

storage :

Desiccate at RT

observed molecular weight :

445.96

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

YIL 781 hydrochloride is a ghrelin receptor antagonist (GHS-R1a) (Ki = 17 nM). Displays no significant affinity for the motilin receptor (Ki = 6 M). Blocks the effects of ghrelin on insulin secretion both in vivo and in vitro . Improves glucose homeostasis in vivo .

product keywords :

YIL781 YIL 781 hydrochloride HCl ghrelin receptors antagonists GHS-R1a GHSR Ghrelin Receptors 3959,

extended description :

Ghrelin receptor (GHS-R1a) antagonist

chemical name text :

6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone hydrochloride

formula :

C24H28FN3O2.HCl

formula text :

C24H28FN3O2.HCl

cas num :

1640226-17-0

USD :

156

USD 2025 :

158 USD

product details :

Ghrelin receptor (GHS-R1a) antagonist

more info or order :

Tocris Bioscience product webpage