cis-Ned 19 | Tocris Bioscience 3953/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

cis-Ned 19

catalog :

3953/10

quantity :

10 mg

price :

425 USD

citations: 2

Reference
Gerasimenko J, Charlesworth R, Sherwood M, Ferdek P, Mikoshiba K, Parrington J, et al. Both RyRs and TPCs are required for NAADP-induced intracellular CaÂ²âº release. Cell Calcium. 2015;58:237-45 pubmed publisher
Favia A, Desideri M, Gambara G, D Alessio A, Ruas M, Esposito B, et al. VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling. Proc Natl Acad Sci U S A. 2014;111:E4706-15 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3953

SKU :

3953/10

product name :

cis-Ned 19

description :

NAADP antagonist; inhibits Ca2+ release

target :

Calcium Signaling Agents

unit size :

10 mg

category :

Small Molecules

purity :

97%

storage :

Store at -20°C

observed molecular weight :

514.59

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

cis -Ned 19 is an irreversible nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist; inhibits Ca2+ release (IC50 = 800 nM) and [32P]NAADP binding (IC50 = 15 M). Stereoisomer of trans -Ned 19 . Fluorescently labels NAADP receptors in intact cells (excitation 351 and 365 nm using an ultraviolet Argon laser). . Isomer of trans -Ned 19 .

product keywords :

cis-Ned19 NAADP nicotinic acid adenine dinucleotide phosphate antagonists calcium signaling signalling inhibitors inhibits fluorescent probes ned19 General Calcium Signaling Agents 3953, trans-NED 19, trans-NED19, ned K,

extended description :

NAADP antagonist; inhibits Ca2+ release

chemical name text :

(1S,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

formula :

C30H31FN4O3

formula text :

C30H31FN4O3

cas num :

1137264-00-6

USD :

420

USD 2025 :

425 USD

product details :

NAADP antagonist; inhibits Ca2+ release