Terfenadine | Tocris Bioscience 3948 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Terfenadine

catalog :

3948

quantity :

50 mg

price :

63 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Pérez Gómez A, Carretero M, Weber N, Peterka V, To A, Titova V, et al. A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia. Nat Commun. 2018;9:5272 pubmed publisher
Klingerman C, Stipanovic M, Bader M, Lynch C. Second-generation antipsychotics cause a rapid switch to fat oxidation that is required for survival in C57BL/6J mice. Schizophr Bull. 2014;40:327-40 pubmed publisher
Francis H, Demorrow S, Venter J, Onori P, White M, Gaudio E, et al. Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinoma. Gut. 2012;61:753-64 pubmed publisher

product information

brand :

Tocris

master code :

3948

SKU :

3948/50

product name :

Terfenadine

description :

H1 antagonist. Also KV11.1 (hERG) and Kir6 (KATP) channel blocker

target :

Histamine H1 Receptor Antagonists

category :

Small Molecules

unit size :

50 mg

purity :

98%

observed molecular weight :

471.67

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Histamine H1 receptor antagonist. Also blocks KV11.1 (hERG) and Kir6 (KATP) channels (IC50 values are 204 nM and 1.2 M respectively). Inhibits the delayed rectifier K+ current (IKr) in guinea pig ventricular myocytes (IC50 = 50 nM). Activity prolongs QT and induces Torsades de pointes (TdP); cardiotoxic in vivo .

catalog number base :

3948

product keywords :

hERG Human Ether-A-Go-Go Gene KV11.1 KIR6 K+ channel blockers histamine H1 antagonists histaminergic Potassium KV KATP Channels voltage-gated voltage-dependent Receptors a-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol Voltage-Gated Potassium Channels Histamine H1 Receptors Inward rectifier Potassium Channels 3948,

extended description :

H1 antagonist. Also KV11.1 (hERG) and Kir6 (KATP) channel blocker

chemical name text :

-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol

formula :

C 32 H 41 NO 2

formula text :

C32H41NO2

cas num :

50679-08-8

2020 USD :

2021 USD :

63 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage