YM 58483 | Tocris Bioscience 3939 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

YM 58483

catalog :

3939

quantity :

10 mg (also 50 mg)

price :

227 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Gao X, Gao R, Tian Y, McGonigle P, Barrett J, Dai Y, et al. A store-operated calcium channel inhibitor attenuates collagen-induced arthritis. Br J Pharmacol. 2015;172:2991-3002 pubmed publisher
Gao R, Gao X, Xia J, Tian Y, Barrett J, Dai Y, et al. Potent analgesic effects of a store-operated calcium channel inhibitor. Pain. 2013;154:2034-2044 pubmed publisher

product information

brand :

Tocris

master code :

3939

SKU :

3939/10

product name :

YM 58483

description :

Inhibitor of SOCE in non-excitable cells

target :

Other Calcium Channel Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

421.32

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Blocker of store-operated Ca2+ entry (SOCE), which mediates the activation of non-excitable cells (e.g. lymphocytes). Inhibits calcium release-activated calcium (CRAC) channels; suppresses thapsigargin-induced sustained Ca2+ influx (IC50 = 100 nM). Displays immuno-modulatory and anti-inflammatory effects; suppresses cytokine production and proliferation of T cells in vitro .

catalog number base :

3939

product keywords :

YM58483 inhibitor inhibits CRAC SOCE store-operated channel calcium Ca2+ release activated entry channels inhibitors Btp2 Other Calcium Channels General Calcium Signaling Agents STIM-Orai Channels 3939,

extended description :

Inhibitor of SOCE in non-excitable cells

chemical name text :

N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide

formula :

C 15 H 9 F 6 N 5 OS

formula text :

C15H9F6N5OS

cas num :

223499-30-7

2020 USD :

218

2021 USD :

227 USD

alt names :

Btp2

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage