YM 58483 | Tocris Bioscience 3939/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

YM 58483

catalog :

3939/10

quantity :

10 mg (also 50 mg)

price :

264 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Gao X, Gao R, Tian Y, McGonigle P, Barrett J, Dai Y, et al. A store-operated calcium channel inhibitor attenuates collagen-induced arthritis. Br J Pharmacol. 2015;172:2991-3002 pubmed publisher
Gao R, Gao X, Xia J, Tian Y, Barrett J, Dai Y, et al. Potent analgesic effects of a store-operated calcium channel inhibitor. Pain. 2013;154:2034-2044 pubmed publisher

product information

brand :

Tocris

master code :

3939

SKU :

3939/10

rank :

0.061

product name :

YM 58483

description :

Inhibitor of SOCE in non-excitable cells

target :

Other Calcium Channel Inhibitors

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

YM 58483 is a blocker of store-operated Ca2+ entry (SOCE), which mediates the activation of non-excitable cells (e.g. lymphocytes). Inhibits calcium release-activated calcium (CRAC) channels; suppresses thapsigargin -induced sustained Ca2+ influx (IC50 = 100 nM). Displays immuno-modulatory and anti-inflammatory effects; suppresses cytokine production and proliferation of T cells in vitro .

extended description :

Inhibitor of SOCE in non-excitable cells

chemical name text :

N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide

formula :

C 15 H 9 F 6 N 5 OS

formula text :

C15H9F6N5OS

cas num :

223499-30-7

USD :

264 USD

product details :

Inhibitor of SOCE in non-excitable cells

alt names :

Btp2

storage :

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage