Eeyarestatin I | Tocris Bioscience 3922 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Eeyarestatin I

catalog :

3922

quantity :

10 mg

price :

181 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Eales K, Wilkinson E, Cruickshank G, Tucker J, Tennant D. Verteporfin selectively kills hypoxic glioma cells through iron-binding and increased production of reactive oxygen species. Sci Rep. 2018;8:14358 pubmed publisher
Yi Z, Fang C, Zou J, Xu J, Song W, Du X, et al. Affinity Purification of the Hepatitis C Virus Replicase Identifies Valosin-Containing Protein, a Member of the ATPases Associated with Diverse Cellular Activities Family, as an Active Virus Replication Modulator. J Virol. 2016;90:9953-9966 pubmed publisher
Davis E, Kim J, Menasche B, Sheppard J, Liu X, Tan A, et al. Comparative Haploid Genetic Screens Reveal Divergent Pathways in the Biogenesis and Trafficking of Glycophosphatidylinositol-Anchored Proteins. Cell Rep. 2015;11:1727-36 pubmed publisher
Han D, Di X, Fu Y, Mu T. Combining valosin-containing protein (VCP) inhibition and suberanilohydroxamic acid (SAHA) treatment additively enhances the folding, trafficking, and function of epilepsy-associated Î³-aminobutyric acid, type A (GABAA) receptors. J Biol Chem. 2015;290:325-37 pubmed publisher

product information

brand :

Tocris

master code :

3922

SKU :

3922/10

product name :

Eeyarestatin I

description :

Potent inhibitor of ER-associated protein degradation and translocation

target :

Other ER Stress/UPR Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

630.44

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD). Specifically targets the p97-associated deubiquinating process (PAD) and inhibits ataxin-3 (atx3)-dependent deubiquitination. Also inhibits Sec61-mediated protein translocation at the ER. Displays cytotoxic activity preferentially against cancer cells; induces cell death via the proapoptotic protein NOXA. Also enhances adeno-acssociated viral transduction in multiple cells types.

catalog number base :

3922

product keywords :

endoplasmic reticulum ER associated protein degradation ERAD translocation inhibitors inhibits ER-stress viral transduction enhancers enhances Translocation, Exocytosis & Endocytosis Other ER stress/UPR Translocation Viral Transduction Enhancers 3922,

extended description :

Potent inhibitor of ER-associated protein degradation and translocation

chemical name text :

3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineacetic acid 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide

formula :

C 27 H 25 Cl 2 N 7 O 7

formula text :

C27H25Cl2N7O7

cas num :

412960-54-4

2020 USD :

174

2021 USD :

181 USD

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage