Eeyarestatin I | Tocris Bioscience 3922/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Eeyarestatin I

catalog :

3922/10

quantity :

10 mg

price :

232 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Pradeep Yeola A, Akbar I, Baillargeon J, Mercy Ignatius Arokia Doss P, Paavilainen V, Rangachari M. Protein translocation and retro-translocation across the endoplasmic reticulum are crucial to inflammatory effector CD4+ T cell function. Cytokine. 2020;129:154944 pubmed publisher
Eales K, Wilkinson E, Cruickshank G, Tucker J, Tennant D. Verteporfin selectively kills hypoxic glioma cells through iron-binding and increased production of reactive oxygen species. Sci Rep. 2018;8:14358 pubmed publisher
Yi Z, Yuan Z. Aggregation of a hepatitis C virus replicase module induced by ablation of p97/VCP. J Gen Virol. 2017;98:1667-1678 pubmed publisher
Yi Z, Fang C, Zou J, Xu J, Song W, Du X, et al. Affinity Purification of the Hepatitis C Virus Replicase Identifies Valosin-Containing Protein, a Member of the ATPases Associated with Diverse Cellular Activities Family, as an Active Virus Replication Modulator. J Virol. 2016;90:9953-9966 pubmed publisher
Di X, Wang Y, Han D, Fu Y, Duerfeldt A, Blagg B, et al. Grp94 Protein Delivers Î³-Aminobutyric Acid Type A (GABAA) Receptors to Hrd1 Protein-mediated Endoplasmic Reticulum-associated Degradation. J Biol Chem. 2016;291:9526-39 pubmed publisher
Davis E, Kim J, Menasche B, Sheppard J, Liu X, Tan A, et al. Comparative Haploid Genetic Screens Reveal Divergent Pathways in the Biogenesis and Trafficking of Glycophosphatidylinositol-Anchored Proteins. Cell Rep. 2015;11:1727-36 pubmed publisher
Han D, Di X, Fu Y, Mu T. Combining valosin-containing protein (VCP) inhibition and suberanilohydroxamic acid (SAHA) treatment additively enhances the folding, trafficking, and function of epilepsy-associated Î³-aminobutyric acid, type A (GABAA) receptors. J Biol Chem. 2015;290:325-37 pubmed publisher
Wang H, Yu X, Guo C, Zuo D, Fisher P, Subjeck J, et al. Enhanced endoplasmic reticulum entry of tumor antigen is crucial for cross-presentation induced by dendritic cell-targeted vaccination. J Immunol. 2013;191:6010-21 pubmed publisher
Zhong S, Xu J, Li P, Tsukamoto H. Caveosomal oxidative stress causes Src-p21ras activation and lysine 63 TRAF6 protein polyubiquitination in iron-induced M1 hepatic macrophage activation. J Biol Chem. 2012;287:32078-84 pubmed publisher

image

image 1 :

Cat.No. 3922 - Eeyarestatin I C27H25Cl2N7O7 CAS No. 412960-54-4

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3922

SKU :

3922/10

product name :

Eeyarestatin I

description :

Potent inhibitor of ER-associated protein degradation and translocation

target :

Other ER Stress/UPR Inhibitors

unit size :

10 mg

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

630.44

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD). Specifically targets the p97-associated deubiquitinating process (PAD) and inhibits ataxin-3 (atx3)-dependent deubiquitination. Also inhibits Sec61-mediated protein translocation at the ER. Displays cytotoxic activity preferentially against cancer cells; induces cell death via the proapoptotic protein NOXA. Also enhances adeno-associated viral transduction in multiple cells types.

product keywords :

endoplasmic reticulum ER associated protein degradation ERAD translocation inhibitors inhibits ER-stress viral transduction enhancers enhances Other ER stress/UPR Translocation Viral Transduction Enhancers 3922,

extended description :

Potent inhibitor of ER-associated protein degradation and translocation

chemical name text :

3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineacetic acid 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide

formula :

C27H25Cl2N7O7

formula text :

C27H25Cl2N7O7

cas num :

412960-54-4

USD :

225

USD 2025 :

232 USD

product details :

Potent inhibitor of ER-associated protein degradation and translocation

more info or order :

Tocris Bioscience product webpage