AMG 548 | Tocris Bioscience 3920/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AMG 548

catalog :

3920/10

quantity :

10 mg

price :

363 USD

citations: 3

Reference
Lenz T, St xfc hler K. Small Molecule Arranged Thermal Proximity Coaggregation (smarTPCA)-A Novel Approach to Characterize Protein-Protein Interactions in Living Cells by Similar Isothermal Dose-Responses. Int J Mol Sci. 2022;23: pubmed publisher
Jafari R, Almqvist H, Axelsson H, Ignatushchenko M, Lundb xe4 ck T, Nordlund P, et al. The cellular thermal shift assay for evaluating drug target interactions in cells. Nat Protoc. 2014;9:2100-22 pubmed publisher
Eckle T, Brodsky K, Bonney M, Packard T, Han J, Borchers C, et al. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol. 2013;11:e1001665 pubmed publisher

product information

brand :

Tocris

master code :

3920

SKU :

3920/10

product name :

AMG 548

unit size :

10 mg

seo description :

Potent and selective p38 inhibitor

target :

p38 Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

461.56

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AMG 548 is a potent and selective inhibitor of p38 (Ki values are 0.5, 3.6, 2600 and 4100 nM for p38 , p38 , p38 and p38 respectively). Displays 1000-fold selectivity against 36 other kinases; inhibits whole blood LPS-stimulated TNF (IC50 = 3 nM). Efficacious in acute and chronic models of arthritis.

top caption :

Potent and selective p38 inhibitor

extended description :

Potent and selective p38 inhibitor

chemical name text :

2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone

formula :

C29H27N5O

formula text :

C29H27N5O

cas num :

864249-60-5

USD :

363 USD

product details :

Potent and selective p38 inhibitor

storage :

Store at -20░C