VX 745 | Tocris Bioscience 3915 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

VX 745

catalog :

3915

quantity :

10 mg (also 50 mg)

price :

239 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Singh R, Diwan M, Dastidar S, Najmi A. Differential effect of p38 and MK2 kinase inhibitors on the inflammatory and toxicity biomarkers in vitro. Hum Exp Toxicol. 2018;37:521-531 pubmed publisher
Haas D, Bala K, Büsche G, Weidner Glunde M, Santag S, Kati S, et al. The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells. PLoS Pathog. 2013;9:e1003737 pubmed publisher

product information

brand :

Tocris

master code :

3915

SKU :

3915/10

product name :

VX 745

description :

Potent and selective p38 inhibitor

target :

p38 Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

436.26

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Highly potent and selective p38 inhibitor (IC50 = 10 nM). Also blocks TNF production in LPS-stimulated HWB in vitro (IC50 = 177 nM). Displays 1000-fold selectivity over closely related kinases, including ERK1, MK2 and JNK1-3.

catalog number base :

3915

product keywords :

VX745 p38a p38alpha p38 MAPK inhibitors inhibits selective potent p38 3915,

extended description :

Potent and selective p38 inhibitor

chemical name text :

5-(2,6-Dichlorophenyl)-2-[2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one

formula :

C 19 H 9 Cl 2 F 2 N 3 OS

formula text :

C19H9Cl2F2N3OS

cas num :

209410-46-8

2020 USD :

232

2021 USD :

239 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage