VX 745 | Tocris Bioscience 3915/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

VX 745

catalog :

3915/10

quantity :

10 mg (also 50 mg)

price :

277 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Singh R, Diwan M, Dastidar S, Najmi A. Differential effect of p38 and MK2 kinase inhibitors on the inflammatory and toxicity biomarkers in vitro. Hum Exp Toxicol. 2018;37:521-531 pubmed publisher
Haas D, Bala K, Büsche G, Weidner Glunde M, Santag S, Kati S, et al. The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells. PLoS Pathog. 2013;9:e1003737 pubmed publisher

image

image 1 :

Cat.No. 3915 - VX 745 C19H9Cl2F2N3OS CAS No. 209410-46-8

product information

brand :

Tocris

master code :

3915

SKU :

3915/10

rank :

0.061

product name :

VX 745

description :

Potent and selective p38 inhibitor

target :

p38 Inhibitors

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

VX 745 is a highly potent and selective p38 /MAPK14 inhibitor, also inhibits p38 (IC50 values are 10 nM and 220 nM respectively). VX 745 blocks TNF production in LPS-stimulated HWB in vitro (IC50 = 51-180 nM). Also reduces phosphorylation of p38MAPK and the downstream target Hsp27, leading to vasodilation, reduces IL-1 levels and amyloid plaques in cortex and hippocampus and lowers CSF tau levels in vivo .

extended description :

Potent and selective p38 inhibitor

chemical name text :

5-(2,6-Dichlorophenyl)-2-[2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one

formula :

C 19 H 9 Cl 2 F 2 N 3 OS

formula text :

C19H9Cl2F2N3OS

cas num :

209410-46-8

USD :

277 USD

product details :

Potent and selective p38 inhibitor

alt names :

VX745, VX-745, Neflamapimod

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage