product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
HX 531
catalog :
3912
quantity :
10 mg (also 50 mg)
price :
269 USD
more info or order :
citations: 7
Reference
Edwards L, Watt J, Webster T, Schlezinger J. Assessment of total, ligand-induced peroxisome proliferator activated receptor γ ligand activity in serum. Environ Health. 2019;18:45 pubmed publisher
Wnuk A, Rzemieniec J, Lasoń W, Krzeptowski W, Kajta M. Benzophenone-3 Impairs Autophagy, Alters Epigenetic Status, and Disrupts Retinoid X Receptor Signaling in Apoptotic Neuronal Cells. Mol Neurobiol. 2018;55:5059-5074 pubmed publisher
Nie B, Nie T, Hui X, Gu P, Mao L, Li K, et al. Brown Adipogenic Reprogramming Induced by a Small Molecule. Cell Rep. 2017;18:624-635 pubmed publisher
Yang X, Ding Y, Li W, Zhang R, Wu J, Ling E, et al. Effects of electroacupuncture and the retinoid X receptor (RXR) signalling pathway on oligodendrocyte differentiation in the demyelinated spinal cord of rats. Acupunct Med. 2017;35:122-132 pubmed publisher
Wnuk A, Rzemieniec J, Litwa E, Lasoń W, Krzeptowski W, Wójtowicz A, et al. The Crucial Involvement of Retinoid X Receptors in DDE Neurotoxicity. Neurotox Res. 2016;29:155-72 pubmed publisher
Cherian M, Lin W, Wu J, Chen T. CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor. Mol Pharmacol. 2015;87:878-89 pubmed publisher
Summermatter S, Santos G, Perez Schindler J, Handschin C. Skeletal muscle PGC-1? controls whole-body lactate homeostasis through estrogen-related receptor ?-dependent activation of LDH B and repression of LDH A. Proc Natl Acad Sci U S A. 2013;110:8738-43 pubmed publisher
product information
brand :
Tocris
master code :
3912
SKU :
3912/10
product name :
HX 531
description :
Potent RXR antagonist
target :
Retinoid X Receptor Antagonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
483.56
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Potent RXR antagonist (IC50 = 18 nM). Promotes white and brown pre-adipocyte differentiation into white adipocytes. Also inhibits bexarotene -induced brown adipogenic reprogramming of myoblasts.
catalog number base :
3912
product keywords :
HX531 rxrs retinoids x receptors antagonists potent stem cell differentiation adipocytes Retinoid X Receptor 3912,
extended description :
Potent RXR antagonist
chemical name text :
4-(7,8,9,10-Tetrahydro-5,7,7,10.10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]-diazepin-12-yl)-benzoic acid
formula :
C 29 H 29 N 3 O 4
formula text :
C29H29N3O4
cas num :
188844-34-0
2020 USD :
258
2021 USD :
269 USD
storage :
Store at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK