API-1 | Tocris Bioscience 3897/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

API-1

catalog :

3897/10

quantity :

10 mg

price :

430 USD

citations: 4

Reference
Jezierska Drutel A, Attaran S, Hopkins B, Skoko J, Rosenzweig S, Neumann C. The peroxidase PRDX1 inhibits the activated phenotype in mammary fibroblasts through regulating c-Jun N-terminal kinases. BMC Cancer. 2019;19:812 pubmed publisher
Karaboğa Arslan A, Yerer M. ?-Chaconine and ?-Solanine Inhibit RL95-2 Endometrium Cancer Cell Proliferation by Reducing Expression of Akt (Ser473) and ER? (Ser167). Nutrients. 2018;10: pubmed publisher
Shamblott M, O Driscoll M, Gomez D, McGuire D. Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2 (TRKB) signaling in the adult human exocrine pancreas. Cell Commun Signal. 2016;14:23 pubmed
Zhu J, Sun L, Lin S, Zhao R, Zhou L, Fang D, et al. BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells. J Exp Clin Cancer Res. 2012;31:31 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

3897

SKU :

3897/10

product name :

API-1

Description :

Selective Akt/PKB inhibitor. Antitumor

target :

Akt (Protein Kinase B) Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

96%

observed molecular weight :

337.29

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

API-1 is an Akt/protein kinase B (PKB) inhibitor. Binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation. Inhibits EGF-induced kinase activity of Akt1, Akt2 and Akt3. Induces cell growth arrest and apoptosis in human cancer cells expressing constitutively active Akt. Displays antitumor activity in vitro and in vivo .

extended description :

Selective Akt/PKB inhibitor. Antitumor

chemical name text :

4-Amino-5,8-dihydro-5-oxo-8- -D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide

formula :

C 13 H 15 N 5 O 6

formula text :

C13H15N5O6

cas num :

36707-00-3

USD :

430 USD

product details :

Selective Akt/PKB inhibitor. Antitumor

storage :

Store at RT