product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
NS 309
catalog :
3895
quantity :
10 mg (also 50 mg)
price :
102 USD
more info or order :
citations: 6
Reference
Hakim M, Buchholz J, Behringer E. Electrical dynamics of isolated cerebral and skeletal muscle endothelial tubes: Differential roles of G-protein-coupled receptors and K+ channels. Pharmacol Res Perspect. 2018;6:e00391 pubmed publisher
Zhang M, Meng X, Zhang J, Cui M, Logothetis D. Molecular overlap in the regulation of SK channels by small molecules and phosphoinositides. Sci Adv. 2015;1:e1500008 pubmed
Hipólito L, Fakira A, Cabañero D, Blandón R, Carlton S, Morón J, et al. In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model. Pain. 2015;156:849-58 pubmed publisher
Wong P, Roberts R, Randall M. Sex differences in endothelial function in porcine coronary arteries: a role for H2O2 and gap junctions?. Br J Pharmacol. 2014;171:2751-66 pubmed publisher
D Alessandro G, Catalano M, Sciaccaluga M, Chece G, Cipriani R, Rosito M, et al. KCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo. Cell Death Dis. 2013;4:e773 pubmed publisher
Oliveira M, Skinner F, Arshadmansab M, Garcia I, Mello C, Knaus H, et al. Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in pilocarpine-treated epileptic rats. Brain Res. 2010;1348:187-99 pubmed publisher
product information
brand :
Tocris
master code :
3895
SKU :
3895/10
product name :
NS 309
description :
Positive modulator of KCa2 (SK) and KCa3.1 (IK) channels
target :
Ca2+-Activated Potassium Channel Activators
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
231.04
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels.
catalog number base :
3895
product keywords :
NS309 Ca2+-activated potassium K+ KCa channels activators positive modulators small intermediate conductance SK IK KCa2 KCa3 Ca2+-Activated Potassium Channels 3895,
extended description :
Positive modulator of KCa2 (SK) and KCa3.1 (IK) channels
chemical name text :
6,7-Dichloro-1H-indole-2,3-dione 3-oxime
formula :
C 8 H 4 Cl 2 N 2 O 2
formula text :
C8H4Cl2N2O2
cas num :
18711-16-5
2020 USD :
98
2021 USD :
102 USD
storage :
Store at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK