product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
NS 309
catalog :
3895/10
quantity :
10 mg (also 50 mg)
price :
119 USD
more info or order :
citations: 6
Reference
Hakim M, Buchholz J, Behringer E. Electrical dynamics of isolated cerebral and skeletal muscle endothelial tubes: Differential roles of G-protein-coupled receptors and K+ channels. Pharmacol Res Perspect. 2018;6:e00391 pubmed publisher
Zhang M, Meng X, Zhang J, Cui M, Logothetis D. Molecular overlap in the regulation of SK channels by small molecules and phosphoinositides. Sci Adv. 2015;1:e1500008 pubmed
Hipólito L, Fakira A, Cabañero D, Blandón R, Carlton S, Morón J, et al. In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model. Pain. 2015;156:849-58 pubmed publisher
Wong P, Roberts R, Randall M. Sex differences in endothelial function in porcine coronary arteries: a role for H2O2 and gap junctions?. Br J Pharmacol. 2014;171:2751-66 pubmed publisher
D Alessandro G, Catalano M, Sciaccaluga M, Chece G, Cipriani R, Rosito M, et al. KCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo. Cell Death Dis. 2013;4:e773 pubmed publisher
Oliveira M, Skinner F, Arshadmansab M, Garcia I, Mello C, Knaus H, et al. Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in pilocarpine-treated epileptic rats. Brain Res. 2010;1348:187-99 pubmed publisher
product information
brand :
Tocris
master code :
3895
SKU :
3895/10
rank :
0.061
product name :
NS 309
description :
Positive modulator of KCa2 (SK) and KCa3.1 (IK) channels
target :
Ca2+-Activated Potassium Channel Activators
category :
Small Molecules
sizes available :
10 mg (also 50 mg)
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
NS 309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels.
extended description :
Positive modulator of KCa2 (SK) and KCa3.1 (IK) channels
chemical name text :
6,7-Dichloro-1H-indole-2,3-dione 3-oxime
formula :
C 8 H 4 Cl 2 N 2 O 2
formula text :
C8H4Cl2N2O2
cas num :
18711-16-5
USD :
119 USD
product details :
Positive modulator of KCa2 (SK) and KCa3.1 (IK) channels
storage :
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK