PP 121 | Tocris Bioscience 3894/5 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PP 121

catalog :

3894/5

quantity :

5 mg (also 25 mg)

price :

115 USD

citations: 1

Reference
Kim S, Nair D, Romero M, Serna V, Koleske A, Woodruff T, et al. Transient inhibition of p53 homologs protects ovarian function from two distinct apoptotic pathways triggered by anticancer therapies. Cell Death Differ. 2019;26:502-515 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3894

SKU :

3894/5

product name :

PP 121

description :

Dual kinase inhibitor; inhibits PI 3-K family kinases

target :

PI 3-Kinase Inhibitors

unit size :

5 mg (also 25 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

319.36

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PP 121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 0.02 M for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 0.06 M for p110 , DNA-PK and mTOR). Exhibits no significant effect on receptor serine/threonine kinases (RSTKs). Blocks the proliferation of tumor cells by direct inhibition of PI 3-K, mTOR, Src and the VEGF receptor.

product keywords :

PP121 PI 3-K PI 3-kinase PI3K dual inhibitors inhibits receptor tyrosine kinases RTKs PI 3-Kinase mTOR Other RTKs 3894,

extended description :

Dual kinase inhibitor; inhibits PI 3-K family kinases

chemical name text :

1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

formula :

C17H17N7

formula text :

C17H17N7

cas num :

1092788-83-4

USD :

127

USD 2025 :

115 USD

product details :

Dual kinase inhibitor; inhibits PI 3-K family kinases