VU 590 dihydrochloride | Tocris Bioscience 3891 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

VU 590 dihydrochloride

catalog :

3891

quantity :

10 mg (also 50 mg)

price :

122 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Yin W, Kim H, Wang S, Gunawan F, Wang L, Kishimoto K, et al. The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis. Nat Commun. 2018;9:2815 pubmed publisher
Bhave G, Chauder B, Liu W, Dawson E, Kadakia R, Nguyen T, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011;79:42-50 pubmed publisher

product information

brand :

Tocris

master code :

3891

SKU :

3891/10

product name :

VU 590 dihydrochloride

description :

Inhibitor of Kir1.1 (ROMK) and Kir7.1

target :

Inward Rectifier Potassium Channel Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

97%

observed molecular weight :

561.46

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibits the renal outer medullary potassium channel (Kir1.1, ROMK) (IC50 = 294 nM). Also inhibits the inward retifying K+ channel Kir7.1; displays no effect upon Kir2.1 or Kir4.1. Acts as an intracellular Kir1.1 channel pore blocker.

catalog number base :

3891

product keywords :

Inhibitor inhibitors inhibits ROMK Kir7.1 ion channel blocker blocks permeability VU590 dihydrochloride renal outer medullary potassium inward rectifying K+ channels Kir1.1 VU590 dihydrochloride Inward rectifier Potassium Channels 3891,

extended description :

Inhibitor of Kir1.1 (ROMK) and Kir7.1

chemical name text :

7,13-Bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane dihydrochloride

formula :

C 24 H 32 N 4 O 7 .2HCl

formula text :

C24H32N4O7.2HCl

cas num :

1783987-83-6

2020 USD :

119

2021 USD :

122 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage