GANT 58 | Tocris Bioscience 3889 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GANT 58

catalog :

3889

quantity :

10 mg (also 50 mg)

price :

173 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Oladapo H, Tarpley M, Sauer S, Addo K, Ingram S, Strepay D, et al. Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells. Cancer Lett. 2017;411:136-149 pubmed publisher

product information

brand :

Tocris

master code :

3889

SKU :

3889/10

product name :

GANT 58

description :

GLI1 antagonist; inhibits Hedgehog (Hh) signaling

target :

Hedgehog Signaling Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

392.48

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GLI antagonist that inhibits GLI1-induced transcription (IC50 = 5 M). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo .

catalog number base :

3889

product keywords :

GANT58 GLI1 inhibits inhibitors downstream Hedgehog signalling signaling Gli antagonists Hh Hedgehog Signaling Stem Cell Signaling 3889,

extended description :

GLI1 antagonist; inhibits Hedgehog (Hh) signaling

chemical name text :

2,3,4,5-Tetra(4-pyridyl)thiophene

formula :

C 24 H 16 N 4 S

formula text :

C24H16N4S

cas num :

64048-12-0

2020 USD :

173

2021 USD :

173 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage