VU 0240551 | Tocris Bioscience 3888 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

VU 0240551

catalog :

3888

quantity :

10 mg (also 50 mg)

price :

195 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Ferando I, Faas G, Mody I. Diminished KCC2 confounds synapse specificity of LTP during senescence. Nat Neurosci. 2016;19:1197-200 pubmed publisher
Lavertu G, Côté S, De Koninck Y. Enhancing K-Cl co-transport restores normal spinothalamic sensory coding in a neuropathic pain model. Brain. 2014;137:724-38 pubmed publisher
Gagnon M, Bergeron M, Lavertu G, Castonguay A, Tripathy S, Bonin R, et al. Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat Med. 2013;19:1524-8 pubmed publisher
Haam J, Popescu I, Morton L, Halmos K, Teruyama R, Ueta Y, et al. GABA is excitatory in adult vasopressinergic neuroendocrine cells. J Neurosci. 2012;32:572-82 pubmed publisher
Doyon N, Prescott S, Castonguay A, Godin A, Kröger H, De Koninck Y. Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis. PLoS Comput Biol. 2011;7:e1002149 pubmed publisher

product information

brand :

Tocris

master code :

3888

SKU :

3888/10

product name :

VU 0240551

description :

KCC2 inhibitor

target :

Other Ion Pump/Transporter Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

342.43

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC50 = 560 nM for K+ uptake assay in KCC2-overexpressing cells). Exhibits selectivity over the Na-K-2Cl cotransporter, NKCCl. Also inhibits hERG and L-type Ca2+ channels.

catalog number base :

3888

product keywords :

cotransporter potassium chloride transport KCC2 Neuronal cotransport SLC12A5 Na+/2Cl-/K+ NKCC1 NKCC2 inhibitors inhibits Ion Pumps K-Cl VU0240551 epilepsy K+/Cl- Cotransporter 2 3888, SLC 12A5, SLC12 A5, KCC 2, Solute Carrier Family 12 (Potassium/Chloride Transporters) Member 3, Potassium-chloride cotransporter, Neuronal K-Cl cotransporter, K-Cl symporter, Electroneutral potassium-chloride cotransporter 22

extended description :

KCC2 inhibitor

chemical name text :

N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide

formula :

C 16 H 14 N 4 OS 2

formula text :

C16H14N4OS2

cas num :

893990-34-6

2020 USD :

187

2021 USD :

195 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage