VU 0240551 | Tocris Bioscience 3888/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

VU 0240551

catalog :

3888/10

quantity :

10 mg (also 50 mg)

price :

243 USD

citations: 8

Reference
Bilchak J, Yeakle K, Caron G, Malloy D, Côté M. Enhancing KCC2 activity decreases hyperreflexia and spasticity after chronic spinal cord injury. Exp Neurol. 2021;338:113605 pubmed publisher
Lorenzo L, Godin A, Ferrini F, Bachand K, Plasencia Fernandez I, Labrecque S, et al. Enhancing neuronal chloride extrusion rescues α2/α3 GABAA-mediated analgesia in neuropathic pain. Nat Commun. 2020;11:869 pubmed publisher
Hildebrand M, Xu J, Dedek A, Li Y, Sengar A, Beggs S, et al. Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing. Cell Rep. 2016;17:2753-2765 pubmed publisher
Ferando I, Faas G, Mody I. Diminished KCC2 confounds synapse specificity of LTP during senescence. Nat Neurosci. 2016;19:1197-200 pubmed publisher
Lavertu G, Côté S, De Koninck Y. Enhancing K-Cl co-transport restores normal spinothalamic sensory coding in a neuropathic pain model. Brain. 2014;137:724-38 pubmed publisher
Gagnon M, Bergeron M, Lavertu G, Castonguay A, Tripathy S, Bonin R, et al. Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat Med. 2013;19:1524-8 pubmed publisher
Haam J, Popescu I, Morton L, Halmos K, Teruyama R, Ueta Y, et al. GABA is excitatory in adult vasopressinergic neuroendocrine cells. J Neurosci. 2012;32:572-82 pubmed publisher
Doyon N, Prescott S, Castonguay A, Godin A, Kröger H, De Koninck Y. Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis. PLoS Comput Biol. 2011;7:e1002149 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

3888

SKU :

3888/10

product name :

VU 0240551

Description :

KCC2 inhibitor

target :

KCC2 Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

342.43

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

VU 0240551 is an inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC50 = 560 nM for K+ uptake assay in KCC2-overexpressing cells). Exhibits selectivity over the Na-K-2Cl cotransporter, NKCCl. Also inhibits hERG and L-type Ca2+ channels.

extended description :

KCC2 inhibitor

chemical name text :

N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide

formula :

C 16 H 14 N 4 OS 2

formula text :

C16H14N4OS2

cas num :

893990-34-6

USD :

243 USD

product details :

KCC2 inhibitor

storage :

Store at +4°C