product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
EHT 1864
catalog :
3872
quantity :
10 mg (also 50 mg)
price :
240 USD
more info or order :
citations: 19
Reference |
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Xiang R, Stack D, Huston S, Li S, Ogbomo H, Kyei S, et al. Ras-related C3 Botulinum Toxin Substrate (Rac) and Src Family Kinases (SFK) Are Proximal and Essential for Phosphatidylinositol 3-Kinase (PI3K) Activation in Natural Killer (NK) Cell-mediated Direct Cytotoxicity against Cryptococcus neoformans. J Biol Chem. 2016;291:6912-22 pubmed publisher
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Katz E, Sims A, Sproul D, Caldwell H, Dixon M, Meehan R, et al. Targeting of Rac GTPases blocks the spread of intact human breast cancer. Oncotarget. 2012;3:608-19 pubmed
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product information
brand :
Tocris
master code :
3872
SKU :
3872/10
product name :
EHT 1864
description :
Potent Rac family inhibitor
target :
Rho GTPase Inhibitors
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
581.47
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Inhibitor of Rac family GTPases. Blocks activation by direct binding to Rac1, Rac1b, Rac2 and Rac3 (KD values are 40, 50, 60 and 250 nM respectively). Inhibits Rac, Ras and Tiam-induced growth transformation of NIH-3T3 fibroblasts. Reduces -amyloid peptide production in vivo .
catalog number base :
3872
product keywords :
Rac-GEF interaction antioncogenic G Proteins Small transformation Rac1 Rac1b Rac2 Rac3 Ras Tiam inhibits inhibitors GTPases EHT1864 Rho 3872,
extended description :
Potent Rac family inhibitor
chemical name text :
5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride
formula :
C 25 H 27 F 3 N 2 O 4 S.2HCl
formula text :
C25H27F3N2O4S.2HCl
cas num :
754240-09-0
2020 USD :
230
2021 USD :
240 USD
storage :
Store at +4°C
more info or order :
company information

Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
headquarters: UK
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