product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
EHT 1864
catalog :
3872/10
quantity :
10 mg (also 50 mg)
price :
279 USD
more info or order :
citations: 19
Reference |
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Xiang R, Stack D, Huston S, Li S, Ogbomo H, Kyei S, et al. Ras-related C3 Botulinum Toxin Substrate (Rac) and Src Family Kinases (SFK) Are Proximal and Essential for Phosphatidylinositol 3-Kinase (PI3K) Activation in Natural Killer (NK) Cell-mediated Direct Cytotoxicity against Cryptococcus neoformans. J Biol Chem. 2016;291:6912-22 pubmed publisher
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Katz E, Sims A, Sproul D, Caldwell H, Dixon M, Meehan R, et al. Targeting of Rac GTPases blocks the spread of intact human breast cancer. Oncotarget. 2012;3:608-19 pubmed
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product information
brand :
Tocris
master code :
3872
SKU :
3872/10
rank :
0.061
product name :
EHT 1864
description :
Potent Rac family inhibitor
target :
Rho GTPase Inhibitors
category :
Small Molecules
sizes available :
10 mg (also 50 mg)
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
EHT 1864 is an inhibitor of Rac family GTPases. Blocks activation by direct binding to Rac1, Rac1b, Rac2 and Rac3 (KD values are 40, 50, 60 and 250 nM respectively). Inhibits Rac, Ras and Tiam-induced growth transformation of NIH-3T3 fibroblasts. Reduces -amyloid peptide production in vivo .
extended description :
Potent Rac family inhibitor
chemical name text :
5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride
formula :
C 25 H 27 F 3 N 2 O 4 S.2HCl
formula text :
C25H27F3N2O4S.2HCl
cas num :
754240-09-0
USD :
279 USD
product details :
Potent Rac family inhibitor
storage :
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
more info or order :
company information

Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
headquarters: UK
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