CH 223191 | Tocris Bioscience 3858 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CH 223191

catalog :

3858

quantity :

10 mg (also 50 mg)

price :

174 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Giménez Gómez P, Pérez Hernández M, Gutierrez Lopez M, Vidal R, Abuin Martínez C, O Shea E, et al. Increasing kynurenine brain levels reduces ethanol consumption in mice by inhibiting dopamine release in nucleus accumbens. Neuropharmacology. 2018;135:581-591 pubmed publisher
Rao P, Ande A, Sinha N, Kumar A, Kumar S. Effects of Cigarette Smoke Condensate on Oxidative Stress, Apoptotic Cell Death, and HIV Replication in Human Monocytic Cells. PLoS ONE. 2016;11:e0155791 pubmed publisher
Matino D, Gargaro M, Santagostino E, Di Minno M, Castaman G, Morfini M, et al. IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII. J Clin Invest. 2015;125:3766-81 pubmed publisher
D Amato N, Rogers T, Gordon M, Greene L, Cochrane D, Spoelstra N, et al. A TDO2-AhR signaling axis facilitates anoikis resistance and metastasis in triple-negative breast cancer. Cancer Res. 2015;75:4651-64 pubmed publisher
Liu H, Ramachandran I, Gabrilovich D. Regulation of plasmacytoid dendritic cell development in mice by aryl hydrocarbon receptor. Immunol Cell Biol. 2014;92:200-3 pubmed publisher
Dubrovska A, Hartung A, Bouchez L, Walker J, Reddy V, Cho C, et al. CXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AhR signalling. Br J Cancer. 2012;107:43-52 pubmed publisher

image

image 1 :

Cat.No. 3858 - CH 223191 C19H19N5O CAS No. 301326-22-7

product information

brand :

Tocris

master code :

3858

SKU :

3858/10

product name :

CH 223191

description :

Potent aryl hydrocarbon receptor (AhR) antagonist

target :

Aryl Hydrocarbon Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

333.39

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent aryl hydrocarbon receptor (AhR) antagonist (IC50 = 30 nM). Exhibits no AhR agonist-like activity (at concentrations up to 100 M). Inhibits 2,3,7,8-Tetrachlorodibenzo- p -dioxin (TCDD)-induced AhR-dependent transcription in vitro and reduces TCDD-induced toxicity in vivo . Attenuates Th17 differentiation of naive CD4 T cells and promotes expansion of hematopoietic stem cells in vitro .

catalog number base :

3858

product keywords :

CH223191 potent specific agonists aryl hydrocarbon receptors AhR stem cells hematopoietic expansion Aryl Hydrocarbon Receptors Stem Cell Proliferation Other Differentiation Products 3858,

extended description :

Potent aryl hydrocarbon receptor (AhR) antagonist

chemical name text :

1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide

formula :

C 19 H 19 N 5 O

formula text :

C19H19N5O

cas num :

301326-22-7

2020 USD :

167

2021 USD :

174 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage