CH 223191 | Tocris Bioscience 3858/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CH 223191

catalog :

3858/10

quantity :

10 mg (also 50 mg)

price :

217 USD

more info or order :

Tocris Bioscience product webpage

citations: 14

Reference
Damasceno L, Cebinelli G, Fernandes M, Nascimento D, P xfa blio G, Vinolo M, et al. STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program. Cell Rep. 2022;39:110838 pubmed publisher
Lopez D, Al Jaberi F, Damas N, Weinert B, Pus U, Torres Rusillo S, et al. Vitamin D Inhibits IL-22 Production Through a Repressive Vitamin D Response Element in the il22 Promoter. Front Immunol. 2021;12:715059 pubmed publisher
Wise L, Xi Y, Purdy J. Hypoxia-Inducible Factor 1α (HIF1α) Suppresses Virus Replication in Human Cytomegalovirus Infection by Limiting Kynurenine Synthesis. MBio. 2021;12: pubmed publisher
Chang F, Kong S, Wang L, Choi B, Lee H, Kim C, et al. Targeting Actomyosin Contractility Suppresses Malignant Phenotypes of Acute Myeloid Leukemia Cells. Int J Mol Sci. 2020;21: pubmed publisher
Takenaka M, Gabriely G, Rothhammer V, Mascanfroni I, Wheeler M, Chao C, et al. Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39. Nat Neurosci. 2019;22:729-740 pubmed publisher
Bhattarai Y, Williams B, Battaglioli E, Whitaker W, Till L, Grover M, et al. Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion. Cell Host Microbe. 2018;23:775-785.e5 pubmed publisher
Giménez Gómez P, Pérez Hernández M, Gutierrez Lopez M, Vidal R, Abuin Martínez C, O Shea E, et al. Increasing kynurenine brain levels reduces ethanol consumption in mice by inhibiting dopamine release in nucleus accumbens. Neuropharmacology. 2018;135:581-591 pubmed publisher
Shah F, Stepan A, O Mahony A, Velichko S, Folias A, Houle C, et al. Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators. Cell Chem Biol. 2017;24:858-869.e5 pubmed publisher
Rao P, Ande A, Sinha N, Kumar A, Kumar S. Effects of Cigarette Smoke Condensate on Oxidative Stress, Apoptotic Cell Death, and HIV Replication in Human Monocytic Cells. PLoS ONE. 2016;11:e0155791 pubmed publisher
Matino D, Gargaro M, Santagostino E, Di Minno M, Castaman G, Morfini M, et al. IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII. J Clin Invest. 2015;125:3766-81 pubmed publisher
D Amato N, Rogers T, Gordon M, Greene L, Cochrane D, Spoelstra N, et al. A TDO2-AhR signaling axis facilitates anoikis resistance and metastasis in triple-negative breast cancer. Cancer Res. 2015;75:4651-64 pubmed publisher
Cheng Y, Jin U, Allred C, Jayaraman A, Chapkin R, Safe S. Aryl Hydrocarbon Receptor Activity of Tryptophan Metabolites in Young Adult Mouse Colonocytes. Drug Metab Dispos. 2015;43:1536-43 pubmed publisher
Liu H, Ramachandran I, Gabrilovich D. Regulation of plasmacytoid dendritic cell development in mice by aryl hydrocarbon receptor. Immunol Cell Biol. 2014;92:200-3 pubmed publisher
Dubrovska A, Hartung A, Bouchez L, Walker J, Reddy V, Cho C, et al. CXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AhR signalling. Br J Cancer. 2012;107:43-52 pubmed publisher

image

image 1 :

Cat.No. 3858 - CH 223191 C19H19N5O CAS No. 301326-22-7

product information

brand :

Tocris

MasterCode :

3858

SKU :

3858/10

product name :

CH 223191

target :

Aryl Hydrocarbon Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

333.39

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CH 223191 is a potent aryl hydrocarbon receptor (AhR) antagonist (IC50 = 30 nM). Exhibits no AhR agonist-like activity (at concentrations up to 100 M). Inhibits 2,3,7,8-Tetrachlorodibenzo- p -dioxin (TCDD)-induced AhR-dependent transcription in vitro and reduces TCDD-induced toxicity in vivo . Attenuates Th17 differentiation of naive CD4 T cells and promotes expansion of hematopoietic stem cells in vitro .

extended description :

Potent aryl hydrocarbon receptor (AhR) antagonist

chemical name text :

1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide

formula :

C 19 H 19 N 5 O

formula text :

C19H19N5O

cas num :

301326-22-7

USD :

217 USD

product details :

Potent aryl hydrocarbon receptor (AhR) antagonist

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage