Tranylcypromine hydrochloride | Tocris Bioscience 3852 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Tranylcypromine hydrochloride

catalog :

3852

quantity :

50 mg

price :

70 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Sheng C, Jungverdorben J, Wiethoff H, Lin Q, Flitsch L, Eckert D, et al. A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation. Nat Commun. 2018;9:4047 pubmed publisher
Sun J, Ermann J, Niu N, Yan G, Yang Y, Shi Y, et al. Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts. Bone Res. 2018;6:14 pubmed publisher
Li H, Yao Q, Mariscal A, Wu X, Hulse J, Pedersen E, et al. Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation. Nat Commun. 2018;9:1420 pubmed publisher
Ping W, Hu J, Hu G, Song Y, Xia Q, Yao M, et al. Genome-wide DNA methylation analysis reveals that mouse chemical iPSCs have closer epigenetic features to mESCs than OSKM-integrated iPSCs. Cell Death Dis. 2018;9:187 pubmed publisher
Liu P, Chen M, Liu Y, Qi L, Ding S. CRISPR-Based Chromatin Remodeling of the Endogenous Oct4 or Sox2 Locus Enables Reprogramming to Pluripotency. Cell Stem Cell. 2018;22:252-261.e4 pubmed publisher
Zhang M, Lin Y, Sun Y, Zhu S, Zheng J, Liu K, et al. Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation. Cell Stem Cell. 2016;18:653-67 pubmed publisher
Kearns N, Pham H, Tabak B, Genga R, Silverstein N, Garber M, et al. Functional annotation of native enhancers with a Cas9-histone demethylase fusion. Nat Methods. 2015;12:401-403 pubmed publisher
Li Y, Zhang Q, Yin X, Yang W, Du Y, Hou P, et al. Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell Res. 2011;21:196-204 pubmed publisher

product information

brand :

Tocris

master code :

3852

SKU :

3852/50

product name :

Tranylcypromine hydrochloride

description :

Irreversible inhibitor of LSD1; also inhibits MAO

target :

Monoamine Oxidase (MAO) Inhibitors

category :

Small Molecules

unit size :

50 mg

purity :

98%

observed molecular weight :

169.65

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Inhibits histone demethylation. In combination with CHIR 99021 (Cat. No. 4423), enables reprogramming of mouse embryonic fibroblasts transduced by only two factors, Oct4 and Klf4, into induced pluripotent stem (iPS) cells.

catalog number base :

3852

product keywords :

irreversible inhibitors inhibits monoamine oxidase A B MAOA MAOB lysine-specific demethylase 1 LSD1 BCH110 histone demethylases demethylation oxygenases oxidases epigenetics stem cells pluripotency pluripotent oct4 KDM1A 2-PCPA Monoamine Oxidase Other Oxygenases/Oxidases Stem Cell Reprogramming Histone Demethylases 3852,

extended description :

Irreversible inhibitor of LSD1; also inhibits MAO

chemical name text :

( )-trans-2-Phenylcyclopropylamine hydrochloride

formula :

C 9 H 11 N.HCl

formula text :

C9H11N.HCl

cas num :

1986-47-6

2020 USD :

2021 USD :

70 USD

alt names :

2-PCPA

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage