Thiazovivin | Tocris Bioscience 3845/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Thiazovivin

catalog :

3845/10

quantity :

10 mg

price :

521 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Sevilla A, Forero E, Zimmer M, Martínez H, Reggio K, Paull D, et al. Derivation and characterization of the NIH registry human stem cell line NYSCF101 under defined feeder-free conditions. Stem Cell Res. 2018;29:197-201 pubmed publisher
Caires JÃºnior L, Goulart E, Melo U, Araujo B, Alvizi L, Soares Schanoski A, et al. Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells. Nat Commun. 2018;9:475 pubmed publisher
Tumelty K, Higginson Scott N, Fan X, Bajaj P, Knowlton K, Shamashkin M, et al. Identification of direct negative cross-talk between the SLIT2 and bone morphogenetic protein-Gremlin signaling pathways. J Biol Chem. 2018;293:3039-3055 pubmed publisher
Brown K, Loh K, Nusse R. Live Imaging Reveals that the First Division of Differentiating Human Embryonic Stem Cells Often Yields Asymmetric Fates. Cell Rep. 2017;21:301-307 pubmed publisher
Xu Z, Robitaille A, Berndt J, Davidson K, Fischer K, Mathieu J, et al. Wnt/?-catenin signaling promotes self-renewal and inhibits the primed state transition in naïve human embryonic stem cells. Proc Natl Acad Sci U S A. 2016;113:E6382-E6390 pubmed

product information

brand :

Tocris

master code :

3845

SKU :

3845/10

rank :

0.061

product name :

Thiazovivin

description :

ROCK inhibitor ; improves the efficiency of fibroblast reprogramming and induction of iPSCs

target :

Stem Cell Signaling Compounds

category :

Small Molecules

sizes available :

10 mg

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Thiazovivin is a selective, cell-permeable Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor (IC50 = 0.5 M). Thiazovivin enhances the efficiency of fibroblast reprogramming to generate induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614) and PD 0325901 (Cat. No. 4192). Thiazovivin improves the survival of human embryonic stem cells (hESCs) upon trypsinization and increases cell adhesion through the regulation of E-cadherin and significantly improves direct reprogramming efficiency. In combination with Valproic acid, sodium salt (Cat. No. 2815), Purmorphamine (Cat. No. 4551) and A 83-01 (Cat. No. 2939), Thiazovivin can be used to directly reprogram mouse embryonic fibroblasts into chemically induced neural stem cells.

extended description :

ROCK inhibitor ; improves the efficiency of fibroblast reprogramming and induction of iPSCs

chemical name text :

N-Benzyl-[2-(pyrimidin-4-yl)amino]thiazole-4-carboxamide

formula :

C 15 H 13 N 5 OS

formula text :

C15H13N5OS

cas num :

1226056-71-8

USD :

521 USD

product details :

ROCK inhibitor ; improves the efficiency of fibroblast reprogramming and induction of iPSCs

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage