5-Azacytidine | Tocris Bioscience 3842 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5-Azacytidine

catalog :

3842

quantity :

50 mg

price :

64 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Linscott M, Chung W. TET1 regulates fibroblast growth factor 8 transcription in gonadotropin releasing hormone neurons. PLoS ONE. 2019;14:e0220530 pubmed publisher
Chandrakanthan V, Yeola A, Kwan J, Oliver R, Qiao Q, Kang Y, et al. PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells. Proc Natl Acad Sci U S A. 2016;113:E2306-15 pubmed publisher
Bhuvanagiri M, Lewis J, Putzker K, Becker J, Leicht S, Krijgsveld J, et al. 5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion. EMBO Mol Med. 2014;6:1593-609 pubmed publisher
Chong J, Reinecke H, Iwata M, Torok Storb B, Stempien Otero A, Murry C. Progenitor cells identified by PDGFR-alpha expression in the developing and diseased human heart. Stem Cells Dev. 2013;22:1932-43 pubmed publisher
Perera F, Tang W, Herbstman J, Tang D, Levin L, Miller R, et al. Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma. PLoS ONE. 2009;4:e4488 pubmed publisher

product information

brand :

Tocris

master code :

3842

SKU :

3842/50

product name :

5-Azacytidine

description :

DNA methyltransferase inhibitor

target :

Methyltransferase Inhibitors

category :

Small Molecules

unit size :

50 mg

purity :

98%

observed molecular weight :

244.2

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

DNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells; induces differentiation of mesenchymal stem cells into cardiomyocytes.

catalog number base :

3842

product keywords :

DNA methyltransferases methylation inhibits inhibitors DNMT mesenchymal stem cells reprogramming differentiation differentiating cardiomyocytes epigenetics DNA Methyltransferases Stem Cell Reprogramming Mesenchymal Stem Cells Cardiomyocyte Stem Cells 3842,

extended description :

DNA methyltransferase inhibitor

chemical name text :

4-Amino-1- -D-ribofuranosyl-1,3,5-triazin-2(1H)-one

formula :

C 8 H 12 N 4 O 5

formula text :

C8H12N4O5

cas num :

320-67-2

2020 USD :

2021 USD :

64 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage