HPI 1 | Tocris Bioscience 3839/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

HPI 1

catalog :

3839/10

quantity :

10 mg (also 50 mg)

price :

228 USD

citations: 1

Reference
Huang L, Desai R, Conrad D, Leite N, Akshinthala D, Lim C, et al. Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids. Cell Stem Cell. 2021;28:1090-1104.e6 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

3839

SKU :

3839/10

product name :

HPI 1

Description :

Inhibits Hedgehog signaling

target :

Hedgehog Signaling Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

95%

observed molecular weight :

463.52

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4 and 6 M for Shh-, SAG-, Gli2- and Gli1-induced activation). Also inhibits Hh pathway activation in SmoM2-LIGHT cells (IC50 = 2.5 M); inhibits the proliferation of cerebellar granule neuron precursors expressing SmoM2. Does not inhibit Wnt signaling.

extended description :

Inhibits Hedgehog signaling

chemical name text :

1,4,5,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylic acid 2-methoxyethyl ester

formula :

C 27 H 29 NO 6

formula text :

C27H29NO6

cas num :

599150-20-6

USD :

228 USD

product details :

Inhibits Hedgehog signaling

storage :

Store at -20°C