JZL 184 | Tocris Bioscience 3836 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

JZL 184

catalog :

3836

quantity :

10 mg (also 50 mg)

price :

149 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Argueta D, Perez P, Makriyannis A, DiPatrizio N. Cannabinoid CB1 Receptors Inhibit Gut-Brain Satiation Signaling in Diet-Induced Obesity. Front Physiol. 2019;10:704 pubmed publisher
Hu H, Kruijssen D, Frias C, Rozsa B, Hoogenraad C, Wierenga C. Endocannabinoid Signaling Mediates Local Dendritic Coordination between Excitatory and Inhibitory Synapses. Cell Rep. 2019;27:666-675.e5 pubmed publisher
Martin H, Bernabeu A, Lassalle O, Bouille C, Beurrier C, Pelissier Alicot A, et al. Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex. Front Cell Neurosci. 2015;9:457 pubmed publisher
Bashashati M, Nasser Y, Keenan C, Ho W, Piscitelli F, Nalli M, et al. Inhibiting endocannabinoid biosynthesis: a novel approach to the treatment of constipation. Br J Pharmacol. 2015;172:3099-111 pubmed publisher
Sardinha J, Kelly M, Zhou J, Lehmann C. Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis. Mediators Inflamm. 2014;2014:978678 pubmed publisher
Valdeolivas S, Pazos M, Bisogno T, Piscitelli F, Iannotti F, Allarà M, et al. The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG. Cell Death Dis. 2013;4:e862 pubmed publisher
Maleńczyk K, Jazurek M, Keimpema E, Silvestri C, Janikiewicz J, Mackie K, et al. CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release. J Biol Chem. 2013;288:32685-99 pubmed publisher

product information

brand :

Tocris

master code :

3836

SKU :

3836/10

product name :

JZL 184

description :

Potent MAGL inhibitor

target :

Monoacylglycerol Lipase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

520.49

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective MAGL inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM). Potentiates depolarization-induced suppression of excitability in cerebellar Purkinje neurons. Exhibits 300-fold selectivity for MAGL over FAAH in vitro . Attenuates nociception in neuropathic and inflammatory pain models. Also reduces free fatty acid levels in primary tumors.

catalog number base :

3836

product keywords :

JZL184 MAGL inhibitor MAG lipase monoacylglycerol lipase inhibitors inhibits MGL MAGL 3836, MAGL

extended description :

Potent MAGL inhibitor

chemical name text :

4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 4-nitrophenyl ester

formula :

C 27 H 24 N 2 O 9

formula text :

C27H24N2O9

cas num :

1101854-58-3

2020 USD :

146

2021 USD :

149 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage