KH 7 | Tocris Bioscience 3834 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

KH 7

catalog :

3834

quantity :

10 mg (also 50 mg)

price :

182 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Schnúr A, Premchandar A, Bagdany M, Lukacs G. Phosphorylation-dependent modulation of CFTR macromolecular signalling complex activity by cigarette smoke condensate in airway epithelia. Sci Rep. 2019;9:12706 pubmed publisher
Ishii M, Beeson G, Beeson C, Rohrer B. An improved method for isolation of mitochondria from cell lines that enables reconstitution of calcium-dependent processes. Anal Biochem. 2019;577:52-58 pubmed publisher
Yamada A, Sakase M, Fukushima M, Harayama H. Reconsideration of the evaluation criteria for bull ejaculated sperm motility in the context of rotation. J Reprod Dev. 2018;64:377-384 pubmed publisher
Inda C, Bonfiglio J, Dos Santos Claro P, Senin S, Armando N, Deussing J, et al. cAMP-dependent cell differentiation triggered by activated CRHR1 in hippocampal neuronal cells. Sci Rep. 2017;7:1944 pubmed publisher
Inda C, Dos Santos Claro P, Bonfiglio J, Senin S, Maccarrone G, Turck C, et al. Different cAMP sources are critically involved in G protein-coupled receptor CRHR1 signaling. J Cell Biol. 2016;214:181-95 pubmed publisher
Shahidullah M, Mandal A, Wei G, Levin L, Buck J, Delamere N. Nonpigmented ciliary epithelial cells respond to acetazolamide by a soluble adenylyl cyclase mechanism. Invest Ophthalmol Vis Sci. 2014;55:187-97 pubmed publisher
Chen M, Yi L, Jin X, Liang X, Zhou Y, Zhang T, et al. Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway. Autophagy. 2013;9:2033-45 pubmed publisher
Jahchan N, Dudley J, Mazur P, Flores N, Yang D, Palmerton A, et al. A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discov. 2013;3:1364-77 pubmed publisher
Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach Mansky R, Sacks D, et al. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature. 2012;492:123-7 pubmed publisher

product information

brand :

Tocris

master code :

3834

SKU :

3834/10

product name :

KH 7

description :

Selective soluble adenylyl cyclase inhibitor

target :

Adenylyl Cyclase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

419.3

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective soluble adenylyl cyclase (sAC) inhibitor (IC50 = 3 - 10 M in vivo ). Inert towards transmembrane adenylyl cyclase (tmAC) in vitro and in whole cells at concentrations up to 300 M. Blocks synthesis of cAMP and displays an antiapoptotic effect at concentrations of 1 - 100 M.

catalog number base :

3834

product keywords :

selective adenylyl cyclases inhibitors inhibits soluble sAC KH7 Adenylyl Cyclase 3834,

extended description :

Selective soluble adenylyl cyclase inhibitor

chemical name text :

( )-2-(1H-benzimidazol-2-ylthio)propanoic acid 2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide

formula :

C 17 H 15 BrN 4 O 2 S

formula text :

C17H15BrN4O2S

cas num :

330676-02-3

2020 USD :

175

2021 USD :

182 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage