7,8-Dihydroxyflavone | Tocris Bioscience 3826/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7,8-Dihydroxyflavone

catalog :

3826/10

quantity :

10 mg (also 50 mg)

price :

207 USD

more info or order :

Tocris Bioscience product webpage

citations: 10

Reference
Hyun S, Ko M, Jang S, Lee B, Rho J, Kim K, et al. Bisphenol-A impairs synaptic formation and function by RGS4-mediated regulation of BDNF signaling in the cerebral cortex. Dis Model Mech. 2022;15: pubmed publisher
Greising S, Vasdev A, Zhan W, Sieck G, Mantilla C. Chronic TrkB agonist treatment in old age does not mitigate diaphragm neuromuscular dysfunction. Physiol Rep. 2017;5: pubmed publisher
Shamblott M, O Driscoll M, Gomez D, McGuire D. Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2 (TRKB) signaling in the adult human exocrine pancreas. Cell Commun Signal. 2016;14:23 pubmed
Chitranshi N, Gupta V, Kumar S, Graham S. Exploring the Molecular Interactions of 7,8-Dihydroxyflavone and Its Derivatives with TrkB and VEGFR2 Proteins. Int J Mol Sci. 2015;16:21087-108 pubmed publisher
Chen W, Walwyn W, Ennes H, Kim H, McRoberts J, Marvizon J. BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals. Eur J Neurosci. 2014;39:1439-54 pubmed publisher
Meltser I, Cederroth C, Basinou V, Savelyev S, Lundkvist G, Canlon B. TrkB-mediated protection against circadian sensitivity to noise trauma in the murine cochlea. Curr Biol. 2014;24:658-63 pubmed publisher
al Qudah M, Anderson C, Mahavadi S, Bradley Z, Akbarali H, Murthy K, et al. Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C. Am J Physiol Gastrointest Liver Physiol. 2014;306:G328-37 pubmed publisher
Choi J, Kang J, Park S, Kim S, Moon J, Saadeldin I, et al. Effect of 7,8-dihydroxyflavone as an antioxidant on in vitro maturation of oocytes and development of parthenogenetic embryos in pigs. J Reprod Dev. 2013;59:450-6 pubmed
Abcejo A, Sathish V, Smelter D, Aravamudan B, Thompson M, Hartman W, et al. Brain-derived neurotrophic factor enhances calcium regulatory mechanisms in human airway smooth muscle. PLoS ONE. 2012;7:e44343 pubmed publisher
Mantilla C, Ermilov L. The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission. Muscle Nerve. 2012;45:274-6 pubmed publisher

image

image 1 :

Cat.No. 3826 - 7,8-Dihydroxyflavone C15H10O4 CAS No. 38183-03-8

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3826

SKU :

3826/10

product name :

7,8-Dihydroxyflavone

description :

TrkB agonist

target :

Trk Receptor Agonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

254.24

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

7,8-Dihydroxyflavone is a tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (Kd = 320 nM). Inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo . Exhibits neuroprotective effects in an HD mouse model.

product keywords :

agonists TrkB Neurotrophin Receptors Tyrosine Kinases RTKs 7,8-DHF 7,8-DHF Trk Receptors 3826,

extended description :

TrkB agonist

chemical name text :

7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one

formula :

C15H10O4

formula text :

C15H10O4

cas num :

38183-03-8

USD :

198

USD 2025 :

207 USD

product details :

TrkB agonist

alt names :

7,8-DHF

more info or order :

Tocris Bioscience product webpage