product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
CD 2314
catalog :
3824/10
quantity :
10 mg (also 50 mg)
price :
313 USD
more info or order :
citations: 6
Reference
Matellan C, Lachowski D, Cortés E, Chiam K, Krstic A, Thorpe S, et al. Retinoic acid receptor β modulates mechanosensing and invasion in pancreatic cancer cells via myosin light chain 2. Oncogenesis. 2023;12:23 pubmed publisher
Yuan B, Shi K, Zha J, Cai Y, Gu Y, Huang K, et al. Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway. Cell Death Dis. 2023;14:51 pubmed publisher
Cortés E, Lachowski D, Rice A, Chronopoulos A, Robinson B, Thorpe S, et al. Retinoic Acid Receptor-β Is Downregulated in Hepatocellular Carcinoma and Cirrhosis and Its Expression Inhibits Myosin-Driven Activation and Durotaxis in Hepatic Stellate Cells. Hepatology. 2019;69:785-802 pubmed publisher
El Shahawy M, Reibring C, Neben C, Hallberg K, Marangoni P, Harfe B, et al. Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid. PLoS Genet. 2017;13:e1006914 pubmed publisher
Duprey Díaz M, Blagburn J, Blanco R. Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System after Optic Nerve Injury. PLoS ONE. 2016;11:e0162626 pubmed publisher
Chronopoulos A, Robinson B, Sarper M, Cortés E, Auernheimer V, Lachowski D, et al. ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion. Nat Commun. 2016;7:12630 pubmed publisher
product information
brand :
Tocris
catalog number base :
3824
SKU :
3824/10
product name :
CD 2314
units size :
10 mg (also 50 mg)
description :
Selective RAR agonist
target :
Retinoic Acid Receptor Agonists
category :
Small Molecules
purity :
98%
observed molecular weight :
364.5
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
CD 2314 is a potent and selective RAR receptor agonist (Kd values are 145 and >3760 nM for RAR and RAR receptors respectively; no binding detected at RAR ). Inhibits growth of human HNSCC 22B, 183A and 22A cells (IC50 values are 3.0, 5.7 and 8.0 M respectively).
top caption :
Selective RAR agonist
extended description :
Selective RAR agonist
chemical name text :
5-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)-3-thiophenecarboxylic acid
formula :
C23H24O2S
formula text :
C23H24O2S
cas num :
170355-37-0
USD :
313 USD
product details :
Selective RAR agonist
storage :
Store at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK