product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
ER 50891
catalog :
3823/10
quantity :
10 mg (also 50 mg)
price :
359 USD
more info or order :
citations: 11
Reference
Yuan B, Shi K, Zha J, Cai Y, Gu Y, Huang K, et al. Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway. Cell Death Dis. 2023;14:51 pubmed publisher
Sears K, Gullapalli K, Trivedi D, Mihas A, Bukys M, Jensen J. Controlling neural territory patterning from pluripotency using a systems developmental biology approach. iScience. 2022;25:104133 pubmed publisher
Sun W, Shi A, Ma D, Bolscher J, Nazmi K, Veerman E, et al. All-trans retinoic acid and human salivary histatin-1 promote the spreading and osteogenic activities of pre-osteoblasts in vitro. FEBS Open Bio. 2020;10:396-406 pubmed publisher
Schwartz D, Farley T, Richoz N, Yao C, Shih H, Petermann F, et al. Retinoic Acid Receptor Alpha Represses a Th9 Transcriptional and Epigenomic Program to Reduce Allergic Pathology. Immunity. 2019;50:106-120.e10 pubmed publisher
Bi W, Liu Y, Guo J, Lin Z, Liu J, Zhou M, et al. All-trans retinoic-acid inhibits heterodimeric bone morphogenetic protein 2/7-stimulated osteoclastogenesis, and resorption activity. Cell Biosci. 2018;8:48 pubmed publisher
Wang B, Fu X, Zhu M, Du M. Retinoic acid inhibits white adipogenesis by disrupting GADD45A-mediated Zfp423 DNA demethylation. J Mol Cell Biol. 2017;9:338-349 pubmed publisher
Alves Lopes J, Soder O, Stukenborg J. Testicular organoid generation by a novel in vitro three-layer gradient system. Biomaterials. 2017;130:76-89 pubmed publisher
Li A, Figueroa S, Jiang T, Wu P, Widelitz R, Nie Q, et al. Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme. Nat Commun. 2017;8:ncomms14139 pubmed publisher
Müller P, Doliva R, Busch M, Philippeit C, Stephan H, Dünker N. Additive Effects of Retinoic Acid (RA) and Bone Morphogenetic Protein 4 (BMP-4) Apoptosis Signaling in Retinoblastoma Cell Lines. PLoS ONE. 2015;10:e0131467 pubmed publisher
Centritto F, Paroni G, Bolis M, Garattini S, Kurosaki M, Barzago M, et al. Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression. EMBO Mol Med. 2015;7:950-72 pubmed publisher
Whelan J, Wang L, Chen J, Metts M, Nasser T, McGoldrick L, et al. Retinoids induce integrin-independent lymphocyte adhesion through RAR-α nuclear receptor activity. Biochem Biophys Res Commun. 2014;454:537-42 pubmed publisher
image
image 1 :
Tocris Bioscience 3823/10 image 1
Cat.No. 3823 - ER 50891 C29H24N2O2 CAS No. 187400-85-7
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
3823
SKU :
3823/10
product name :
ER 50891
description :
Selective RAR antagonist
target :
Retinoic Acid Receptor Antagonists
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
99%
storage :
Store at RT
observed molecular weight :
432.51
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
ER 50891 is an antagonist of RAR receptors (IC50 = 31.2 nM). Displays selective affinity for RAR (relative IC50 values are 1.8, 432 and 535 nM for RAR , RAR and RAR respectively).
product keywords :
ER50891 raralpha rara rar receptors antagonists retinoids retinoic acid selective Retinoic Acid Receptors 3823,
extended description :
Selective RAR antagonist
chemical name text :
4-[5-[8-(1-Methylethyl)-4-phenyl-2-quinolinyl]-1H-pyrrolo-2-benzoic acid
formula :
C29H24N2O2
formula text :
C29H24N2O2
cas num :
187400-85-7
USD :
344
USD 2025 :
359 USD
product details :
Selective RAR antagonist
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK