TCS 1102 | Tocris Bioscience 3818 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TCS 1102

catalog :

3818

quantity :

10 mg (also 50 mg)

price :

176 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Khoo S, McNally G, Clemens K. The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking. PLoS ONE. 2017;12:e0173967 pubmed publisher
Dong X, Li Y, Kirouac G. Blocking of orexin receptors in the paraventricular nucleus of the thalamus has no effect on the expression of conditioned fear in rats. Front Behav Neurosci. 2015;9:161 pubmed publisher
Mavanji V, Perez Leighton C, Kotz C, Billington C, Parthasarathy S, Sinton C, et al. Promotion of Wakefulness and Energy Expenditure by Orexin-A in the Ventrolateral Preoptic Area. Sleep. 2015;38:1361-70 pubmed publisher
Putula J, Pihlajamaa T, Kukkonen J. Calcium affects OX1 orexin (hypocretin) receptor responses by modifying both orexin binding and the signal transduction machinery. Br J Pharmacol. 2014;171:5816-28 pubmed publisher
Korim W, Bou Farah L, McMullan S, Verberne A. Orexinergic activation of medullary premotor neurons modulates the adrenal sympathoexcitation to hypothalamic glucoprivation. Diabetes. 2014;63:1895-906 pubmed publisher

product information

brand :

Tocris

master code :

3818

SKU :

3818/10

product name :

TCS 1102

description :

Potent, dual orexin receptor antagonist

target :

Orexin Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

470.59

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively). Inhibits ADL-orexin B-mediated locomotion following i.p. administration in vivo and blocks orexin-A (Cat.No.1455) mediated increases in feeding behaviour. Brain penetrant.

catalog number base :

3818

product keywords :

TCS1102 orexin receptors OX1 OX2 antagonists non-selective dual potent merck Non-selective Orexin 3818,

extended description :

Potent, dual orexin receptor antagonist

chemical name text :

N-[1,1 -Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide

formula :

C 27 H 26 N 4 O 2 S

formula text :

C27H26N4O2S

cas num :

916141-36-1

2020 USD :

176

2021 USD :

176 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage