TCS 1102 | Tocris Bioscience 3818/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TCS 1102

catalog :

3818/10

quantity :

10 mg (also 50 mg)

price :

226 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Du X, Li F, Peng X, Xu B, Zhang Y, Li G, et al. Circadian regulation of developmental synaptogenesis via the hypocretinergic system. Nat Commun. 2023;14:3195 pubmed publisher
Perez S, Lodge D. Orexin Modulation of VTA Dopamine Neuron Activity: Relevance to Schizophrenia. Int J Neuropsychopharmacol. 2021;24:344-353 pubmed publisher
Khoo S, McNally G, Clemens K. The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking. PLoS ONE. 2017;12:e0173967 pubmed publisher
Dong X, Li Y, Kirouac G. Blocking of orexin receptors in the paraventricular nucleus of the thalamus has no effect on the expression of conditioned fear in rats. Front Behav Neurosci. 2015;9:161 pubmed publisher
Mavanji V, Perez Leighton C, Kotz C, Billington C, Parthasarathy S, Sinton C, et al. Promotion of Wakefulness and Energy Expenditure by Orexin-A in the Ventrolateral Preoptic Area. Sleep. 2015;38:1361-70 pubmed publisher
Putula J, Pihlajamaa T, Kukkonen J. Calcium affects OX1 orexin (hypocretin) receptor responses by modifying both orexin binding and the signal transduction machinery. Br J Pharmacol. 2014;171:5816-28 pubmed publisher
Korim W, Bou Farah L, McMullan S, Verberne A. Orexinergic activation of medullary premotor neurons modulates the adrenal sympathoexcitation to hypothalamic glucoprivation. Diabetes. 2014;63:1895-906 pubmed publisher

image

image 1 :

Cat.No. 3818 - TCS 1102 C27H26N4O2S CAS No. 916141-36-1

product information

brand :

Tocris

catalog number base :

3818

SKU :

3818/10

product name :

TCS 1102

units size :

10 mg (also 50 mg)

description :

Potent, dual orexin receptor antagonist

target :

Orexin Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

470.59

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively). Inhibits ADL-orexin B-mediated locomotion following i.p. administration in vivo and blocks orexin-A (Cat.No.1455) mediated increases in feeding behaviour. Brain penetrant.

top caption :

Potent, dual orexin receptor antagonist

extended description :

Potent, dual orexin receptor antagonist

chemical name text :

N-[1,1 -Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide

formula :

C27H26N4O2S

formula text :

C27H26N4O2S

cas num :

916141-36-1

USD :

226 USD

product details :

Potent, dual orexin receptor antagonist

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage