R 568 hydrochloride | Tocris Bioscience 3815 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

R 568 hydrochloride

catalog :

3815

quantity :

10 mg (also 50 mg)

price :

166 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Zhang X, Jin T, Shi N, Yao L, Yang X, Han C, et al. Mechanisms of Pancreatic Injury Induced by Basic Amino Acids Differ Between L-Arginine, L-Ornithine, and L-Histidine. Front Physiol. 2018;9:1922 pubmed publisher
Sun R, Zhang W, Zhong H, Wang L, Tang N, Liu Y, et al. Calcimimetic R568 reduced the blood pressure and improved aortic remodeling in spontaneously hypertensive rats by inhibiting local renin-angiotensin system activity. Exp Ther Med. 2018;16:4089-4099 pubmed publisher
Tang L, Jiang L, McIntyre M, Petrova E, Cheng S. Calcimimetic acts on enteric neuronal CaSR to reverse cholera toxin-induced intestinal electrolyte secretion. Sci Rep. 2018;8:7851 pubmed publisher
Zhang L, Ji T, Wang Q, Meng K, Zhang R, Yang H, et al. Calcium-Sensing Receptor Stimulation in Cultured Glomerular Podocytes Induces TRPC6-Dependent Calcium Entry and RhoA Activation. Cell Physiol Biochem. 2017;43:1777-1789 pubmed publisher
RodrÃguez HernÃ¡ndez C, Mateo Lozano S, GarcÃa M, CasalÃ C, BriansÃ³ F, CastrejÃ³n N, et al. Cinacalcet inhibits neuroblastoma tumor growth and upregulates cancer-testis antigens. Oncotarget. 2016;7:16112-29 pubmed publisher
Yamamura A, Ohara N, Tsukamoto K. Inhibition of Excessive Cell Proliferation by Calcilytics in Idiopathic Pulmonary Arterial Hypertension. PLoS ONE. 2015;10:e0138384 pubmed publisher
Yarova P, Stewart A, Sathish V, Britt R, Thompson M, P Lowe A, et al. Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma. Sci Transl Med. 2015;7:284ra60 pubmed publisher
Engelstoft M, Park W, Sakata I, Kristensen L, Husted A, Osborne Lawrence S, et al. Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Mol Metab. 2013;2:376-92 pubmed publisher
Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach Mansky R, Sacks D, et al. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature. 2012;492:123-7 pubmed publisher
Yamamura A, Guo Q, Yamamura H, Zimnicka A, Pohl N, Smith K, et al. Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension. Circ Res. 2012;111:469-81 pubmed publisher
Cheng S. Calcium-sensing receptor inhibits secretagogue-induced electrolyte secretion by intestine via the enteric nervous system. Am J Physiol Gastrointest Liver Physiol. 2012;303:G60-70 pubmed publisher

product information

brand :

Tocris

master code :

3815

SKU :

3815/10

product name :

R 568 hydrochloride

description :

Positive allosteric modulator of human calcium-sensing receptor (CaSR)

target :

Calcium-Sensing Receptor Modulators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

340.29

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Positive allosteric modulator and allosteric agonist of the human calcium-sensing receptor (hCaSR). Exhibits calcimimetic activity. Has the ability to restore function to hCaSR mutants that cause familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT). Exerts a suppressive effect on parathyroid (PT) hormone secretion; inhibits PT cell proliferation in rats with renal insufficiency.

catalog number base :

3815

product keywords :

R568 hydrochloride HCl allosteric modulators and allosteric agonists calcium-sensing recptor hCaSR PAM Calcium-Sensing Receptor 3815,

extended description :

Positive allosteric modulator of human calcium-sensing receptor (CaSR)

chemical name text :

2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine hydrochloride

formula :

C 18 H 22 ClNO.HCl

formula text :

C18H22ClNO.HCl

cas num :

177172-49-5

2020 USD :

162

2021 USD :

166 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage