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company name :
Tocris Bioscience
product type :
chemical
product name :
VER 155008
catalog :
3803/10
quantity :
10 mg (also 50 mg)
price :
264 USD
more info or order :
citations: 18
Reference
Kim Chiaw P, Hantouche C, Wong M, Matthes E, Robert R, Hanrahan J, et al. Hsp70 and DNAJA2 limit CFTR levels through degradation. PLoS ONE. 2019;14:e0220984 pubmed publisher
Rinaldi L, Delle Donne R, Catalanotti B, Torres Quesada O, Enzler F, Moraca F, et al. Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system. Nat Commun. 2019;10:2572 pubmed publisher
Gleixner A, Hutchison D, Sannino S, Bhatia T, Leak L, Flaherty P, et al. N-Acetyl-l-Cysteine Protects Astrocytes against Proteotoxicity without Recourse to Glutathione. Mol Pharmacol. 2017;92:564-575 pubmed publisher
Ganguly A, Han X, Das U, Wang L, Loi J, Sun J, et al. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin. J Cell Biol. 2017;216:2059-2074 pubmed publisher
Baquero Perez B, Whitehouse A. Hsp70 Isoforms Are Essential for the Formation of Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription Compartments. PLoS Pathog. 2015;11:e1005274 pubmed publisher
Cavanaugh A, Juengst B, Sheridan K, Danella J, Williams H. Combined inhibition of heat shock proteins 90 and 70 leads to simultaneous degradation of the oncogenic signaling proteins involved in muscle invasive bladder cancer. Oncotarget. 2015;6:39821-38 pubmed publisher
O Regan L, Sampson J, Richards M, Knebel A, Roth D, Hood F, et al. Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression. J Cell Biol. 2015;209:349-58 pubmed publisher
Thuringer D, Berthenet K, Cronier L, Jego G, Solary E, Garrido C. Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells. Oncotarget. 2015;6:10267-83 pubmed
Nair S, Arora S, Lim J, Lee L, Lim L. The regulation of TNFα production after heat and endotoxin stimulation is dependent on Annexin-A1 and HSP70. Cell Stress Chaperones. 2015;20:583-93 pubmed publisher
Young C, Sinadinos A, Lefebvre A, Chan P, Arkle S, Vaudry D, et al. A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90. Autophagy. 2015;11:113-30 pubmed publisher
Truman A, Kristjansdottir K, Wolfgeher D, Ricco N, Mayampurath A, Volchenboum S, et al. Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase. J Proteomics. 2015;112:285-300 pubmed publisher
Couceiro J, Gallardo R, De Smet F, De Baets G, Baatsen P, Annaert W, et al. Sequence-dependent internalization of aggregating peptides. J Biol Chem. 2015;290:242-58 pubmed publisher
Rodriguez K, Osmulski P, Pierce A, Weintraub S, Gaczynska M, Buffenstein R. A cytosolic protein factor from the naked mole-rat activates proteasomes of other species and protects these from inhibition. Biochim Biophys Acta. 2014;1842:2060-72 pubmed publisher
Traister A, Walsh M, Aafaqi S, Lu M, Dai X, Henkleman M, et al. Mutation in integrin-linked kinase (ILK(R211A)) and heat-shock protein 70 comprise a broadly cardioprotective complex. PLoS ONE. 2013;8:e77331 pubmed publisher
Marada S, Stewart D, Bodeen W, Han Y, Ogden S. The unfolded protein response selectively targets active smoothened mutants. Mol Cell Biol. 2013;33:2375-87 pubmed publisher
Wiech M, Olszewski M, Tracz Gaszewska Z, Wawrzynow B, Zylicz M, Zylicz A. Molecular mechanism of mutant p53 stabilization: the role of HSP70 and MDM2. PLoS ONE. 2012;7:e51426 pubmed publisher
Shorter J. The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system. PLoS ONE. 2011;6:e26319 pubmed publisher
Boroughs L, Antonyak M, Johnson J, Cerione R. A unique role for heat shock protein 70 and its binding partner tissue transglutaminase in cancer cell migration. J Biol Chem. 2011;286:37094-107 pubmed publisher
product information
brand :
Tocris
master code :
3803
SKU :
3803/10
rank :
0.061
product name :
VER 155008
description :
Hsp70 inhibitor
target :
HSP70 Inhibitors
category :
Small Molecules
sizes available :
10 mg (also 50 mg)
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
VER 155008 is a novel adenosine-derived inhibitor of Heat Shock Protein 70 (Hsp70) (IC50 = 0.5 M). Inhibits cell proliferation of multiple human tumor cell lines in vitro . Also binds Hsc70 and Grp78; displays selectivity against Hsp90 (IC50 200 M for Hsp90 ).
extended description :
Hsp70 inhibitor
chemical name text :
5 -O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
formula :
C 25 H 23 Cl 2 N 7 O 4
formula text :
C25H23Cl2N7O4
cas num :
1134156-31-2
USD :
264 USD
product details :
Hsp70 inhibitor
storage :
Store the unopened product at room temperature. Do not use past expiration date.
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK