Losartan potassium | Tocris Bioscience 3798 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Losartan potassium

catalog :

3798

quantity :

50 mg

price :

110 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Moreno Santos B, Marchi Coelho C, Costa Ferreira W, Crestani C. Angiotensinergic receptors in the medial amygdaloid nucleus differently modulate behavioral responses in the elevated plus-maze and forced swimming test in rats. Behav Brain Res. 2021;397:112947 pubmed publisher
Yoon Lee J, Chung J, Hwa Kim K, Hyun An S, Yi J, Ae Kwon K, et al. Extracorporeal shock waves protect cardiomyocytes from doxorubicin-induced cardiomyopathy by upregulating survivin via the integrin-ILK-Akt-Sp1/p53 axis. Sci Rep. 2019;9:12149 pubmed publisher
Domińska K, Okła P, Kowalska K, Habrowska Górczyńska D, Urbanek K, Ochedalski T, et al. Angiotensin 1-7 modulates molecular and cellular processes central to the pathogenesis of prostate cancer. Sci Rep. 2018;8:15772 pubmed publisher
Thieme K, Oliveira Souza M. Renal hemodynamic and morphological changes after 7 and 28 days of leptin treatment: the participation of angiotensin II via the AT1 receptor. PLoS ONE. 2015;10:e0122265 pubmed publisher
Bhattachariya A, TurczyÅ„ska K, Grossi M, NordstrÃ¶m I, Buckbinder L, Albinsson S, et al. PYK2 selectively mediates signals for growth versus differentiation in response to stretch of spontaneously active vascular smooth muscle. Physiol Rep. 2014;2: pubmed publisher
Santhekadur P, Akiel M, Emdad L, Gredler R, Srivastava J, Rajasekaran D, et al. Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGF? signaling. FEBS Open Bio. 2014;4:353-61 pubmed publisher
Fang J, Angelov S, Simon A, Burt J. Compromised regulation of tissue perfusion and arteriogenesis limit, in an AT1R-independent fashion, recovery of ischemic tissue in Cx40(-/-) mice. Am J Physiol Heart Circ Physiol. 2013;304:H816-27 pubmed publisher
Tsai C, Chan J, Hsu K, Chang A, Chan S. Brain-derived neurotrophic factor ameliorates brain stem cardiovascular dysregulation during experimental temporal lobe status epilepticus. PLoS ONE. 2012;7:e33527 pubmed publisher
Leite Moreira A, Castro Chaves P, Pimentel Nunes P, Lima Carneiro A, Guerra M, Soares J, et al. Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect. Br J Pharmacol. 2006;147:690-7 pubmed

product information

brand :

Tocris

master code :

3798

SKU :

3798/50

product name :

Losartan potassium

description :

Selective, non-peptide AT1 antagonist

target :

Angiotensin AT1 Receptor Antagonists

category :

Small Molecules

unit size :

50 mg

purity :

99%

observed molecular weight :

461

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective non-peptide angiotensin AT1 receptor antagonist. Inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA2 = 8.27). Orally active antihypertensive agent. Attenuates lung damage in a mouse model of SARS-CoV infection.

catalog number base :

3798

product keywords :

Selective non-peptide angiotensin II A-II AT1 receptors antagonists AT-II DuP753 lung injury SARS-CoV coronaviruses DuP-753 Angiotensin AT1 Receptors COVID-19 3798,

extended description :

Selective, non-peptide AT1 antagonist

chemical name text :

2-Butyl-4-chloro-1-[[2 -(1H-tetrazol-5-yl)-[1,1 -biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol potassium salt

formula :

C 22 H 22 ClKN 6 O

formula text :

C22H22ClKN6O

cas num :

124750-99-8

2020 USD :

104

2021 USD :

110 USD

alt names :

DuP-753

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage