BL 1249 | Tocris Bioscience 3797/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BL 1249

catalog :

3797/10

quantity :

10 mg (also 50 mg)

price :

245 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Kanda H, Ling J, Tonomura S, Noguchi K, Matalon S, Gu J. TREK-1 and TRAAK Are Principal K+ Channels at the Nodes of Ranvier for Rapid Action Potential Conduction on Mammalian Myelinated Afferent Nerves. Neuron. 2019;104:960-971.e7 pubmed publisher
Fernández Fernández D, Cadaveira Mosquera A, Rueda Ruzafa L, Herrera Pérez S, Veale E, Reboreda A, et al. Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons. PLoS ONE. 2018;13:e0199282 pubmed publisher

image

image 1 :

Cat.No. 3797 - BL 1249 C17H17N5 CAS No. 18200-13-0

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

3797

SKU :

3797/10

product name :

BL 1249

description :

K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator

target :

Two-P Potassium Channels Activators

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Store at -20°C

observed molecular weight :

291.35

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BL 1249 is a K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channel opener (EC50 values are 5.5 M and 8 M, respectively). Exhibits selectivity for bladder over vascular tissue in vitro and in vivo (EC50 values are 1.26 and 21.0 M for cultured bladder and aortic tissues respectively).

product keywords :

BL1249 potassium channel activators openers K2p2.1 trek-1 kcnk2 tpkc1 bladder selective Two-P Potassium Channels 3797,

extended description :

K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator

chemical name text :

5,6,7,8-Tetrahydro-N-[2-(2H-tetrazol-5-yl)phenyl]-1-naphthalenamine

formula :

C17H17N5

formula text :

C17H17N5

cas num :

18200-13-0

USD :

237

USD 2025 :

245 USD

product details :

K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator

more info or order :

Tocris Bioscience product webpage